53995-05-4Relevant academic research and scientific papers
The highly regioselective synthesis of novel imidazolidin-2-ones via the intramolecular cyclization/electrophilic substitution of urea derivatives and the evaluation of their anticancer activity
Abdullaeva, Dinara S.,Amerhanova, Syumbelya K.,Burilov, Alexander R.,Gazizov, Almir S.,Kuznetsova, Elizaveta A.,Lyubina, Anna P.,Pudovik, Michail A.,Smolobochkin, Andrey V.,Syakaev, Victor V.,Voloshina, Alexandra D.,Voronina, Julia K.
, (2021/08/03)
A series of novel 4-(het)arylimidazoldin-2-ones were obtained by the acid-catalyzed reaction of (2,2-diethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones benefits from excellent regiosele
Preparation and application of imidazolone compounds containing tetrahydroisoquinoline structure
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Paragraph 0023-0024, (2020/05/01)
The invention discloses imidazolone compounds containing a tetrahydroisoquinoline structure represented by figure 1, and an application of the imidazolone compounds as a novel protein arginine methyltransferase 5 inhibitor.
Lithiation of 1-arylimidazol-2(1H)-ones and 1-aryl-4,5-dihydroimidazol- 2(1H)-ones
Llopart, Carme Cantos,Ferrer, Conchita,Joule, John A.
, p. 1649 - 1661 (2007/10/03)
1-Arylimidazol-2(1H)-ones are shown to be readily lithiated, using 2 mol equiv. of n-butyllithium, on the benzene ring, ortho to the heterocycle. 1-Aryl-4,5-dihydroimidazol-2(1H)-ones also undergo metalation on the aromatic substitutuent ortho to the heterocycle, but less efficiently. 1-Aryl-3-methylimidazol-2(1H)-ones are lithiated on the heterocyclic ring and then on the benzene ring ortho to the heterocycle. No ortho-directing effect was found for 1-aryl-4,5-dihydro-3-methylimidazol-2(1H)-ones.
