54-80-8

Basic information

• Product Name: Pronetalol
• Synonyms: Pronetalol;pronethalol;Alderlin;α-[(Isopropylamino)methyl]-2-naphthalenemethanol;α-[[(1-Methylethyl)amino]methyl]naphthalene-2-methanol;Pronethanol;α-[(tert-Butylamino)methyl]-2-naphthalenemethanol;1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol
• CAS NO: 54-80-8
• Molecular Formula: C15H19NO
• Molecular Weight: 229.321
• Product Categories: Aromatics. Pharmaceuticals;Intermediates & Fine Chemicals;ALDERLIN
• Mol File: 54-80-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 108°
• Boiling Point: 371.23°C (rough estimate)
• Flash Point: 84.3°C
• Appearance: /
• Density: 1.0020 (rough estimate)
• Refractive Index: 1.5200 (estimate)
• PKA: 13.91±0.20(Predicted)
• CAS DataBase Reference: Pronetalol(CAS DataBase Reference)
• NIST Chemistry Reference: Pronetalol(54-80-8)
• EPA Substance Registry System: Pronetalol(54-80-8)

Safety Data

• Hazardous Substances Data: 54-80-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 54-80-8 differently. You can refer to the following data:
1. A non-selective beta blocker, not yet used in treatment due to carcinogenic properties.
2. Pronetalol is a kind of beta adrenergic agonist, antiarrhythmic.

InChI:InChI=1/C15H19NO/c1-11(2)16-10-15(17)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11,15-17H,10H2,1-2H3

Upstream product

• 86457-71-8 2-(naphthalen-2-yl)oxirane 
• 108-18-9 diisopropylamine 
• 827-54-3 2-naphthylethylene 
• 93-08-3 methyl 2-naphthyl ketone 
• 613-54-7 2-Bromo-2'-acetonaphthone 
• 20862-01-5 2-naphthylglyoxal aldosine 
• 67-64-1 acetone 
• 5696-74-2 (1RS)-2-amino-1-(2-naphthyl)ethanol 
• 91571-04-9 2-bromo-1-(naphthalen-2-yl)ethan-1-ol 
• 75-31-0 isopropylamine 
• 22115-06-6 2-naphthylglyoxal 
• 20861-93-2 Isopropylaminomethyl-2-naphthyl-keton-hydrobromid 

Downstream Products

• 1085-07-0 N-<2-Chloro-2-(2-naphthyl)ethyl>isopropylamin 

Relevant articles and documents

From simple organobromides or olefins to highly value-added bromohydrins: A versatile performance of dimethyl sulfoxide

A novel and efficient direct transformation of secondary bromides or olefins to highly value-added bromohydrins has been disclosed. Dimethyl sulfoxide (DMSO), a cheap and common solvent, performs its versatile role as a solvent, an essential oxidant, and also as an oxygen source in this bromohydrin synthesis.

ANTIHYPERTENSIVE THERAPY

A new use of darusentan is provided in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy with one or more drugs. The composition comprises darusentan in an amount providing a therapeutically effective daily dose; wherein (a) the composition is orally deliverable and/or (b) the daily dose of darusentan is effective to provide a reduction of at least about 3 mmHg in one or more blood pressure parameters selected from trough sitting systolic, trough sitting diastolic, 24-hour ambulatory systolic, 24-hour ambulatory diastolic, maximum diurnal systolic and maximum diurnal diastolic blood pressures. Further provided is a new use of darusentan in preparation of a pharmaceutical composition for lowering blood pressure in a patient exhibiting resistance to a baseline antihypertensive therapy, wherein the composition is administered adjunctively with at least one diuretic and at least one antihypertensive drug selected from ACE inhibitors, angiotensin II receptor blockers, beta-adrenergic receptor blockers and calcium channel blockers.

Beta-adrenergic blocking agents. I. Pronethalol and related N-alkyl and N-aralkyl derivatives of 2-amino-1-(2-naphythyl)ethanol.

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