540-03-4Relevant academic research and scientific papers
CONSTITUENTS OF THE LIPOPHILIC EXTRACT OF THE FRUITS OF Serenoa repens (BART.) SMALL
Jommi, Giancarlo,Verotta, Luisella,Gariboldi, Pierluigi,Gabetta, Bruno
, p. 823 - 826 (2007/10/02)
The n-hexane extract of the fruits of Serenoa repens contains fatty acids, C6 to C18, their methyl and ethyl esters, farnesol, phytol, geranylgeraniol, 1, n-C22H45OH, n-C23H47OH, n-C24H49OH, n-C26H53OH, n-C28H57OH, β-sitosterol, cycloartenol, 24-methylenecycloartanol, stigmasterol, lupeol and four polyprenols 2-5.The structure of the polyprenols was elucidated by means of GC/MS, 1H- and 13C-NMR, DEPT 13C-NMR analyses.The esters of the alcohols and fatty acids described were also present.
β,γ-dihydropolyprenyl alcohol derivatives and pharmaceutical composition containing a polyprenyl compound
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, (2008/06/13)
A β,γ-dihydropolyprenyl alcohol derivative having the formula: STR1 wherein n is an integer of 5 to 7 and R is hydrogen, a lower alkyl group or an aliphatic or aromatic acyl group, is new and useful as a phylactic agent against human and animal infectious diseases. Other disclosed polyprenyl compounds are also useful as such agents.
GENERAL METHOD OF STEREOSPECIFIC SYNTHESIS OF NATURAL POLYPRENOLS. SYNTHESIS OF BETULAPRENOL-6, -7, -8, AND -9
Sato, Kikumasa,Miyamoto, Osamu,Inoue, Seiichi,Furusawa, Fumio,Matsuhasi, Yasusuke
, p. 1105 - 1108 (2007/10/02)
A stereoselective synthesis of (Z,Z,Z)-12-benzyloxy-1-chloro-2,6,10-trimethyldodeca-2,6,10-triene was achieved starting from (Z,Z)-farnesol.All the components of betulaprenols were synthesized using the C15 block 3 and its lower homologue (C10 block) as t
Stereoselective Synthesis of Solanesol and all-trans-Decaprenol
Sato, Kikumasa,Inoue, Seiichi,Onishi, Akira,Uchida, Nobuhiko,Minowa, Nobuto
, p. 761 - 769 (2007/10/02)
Allylic p-tolyl sulphonates (5), (14), and (16) couple with allylic bromide (7) and geranyl bromide to produce regio- and stereo-chemically pure 1,5-diene systems.The coupling of all-trans-ω-bromogeranyl acetate (7) with geranyl p-tolyl sulphone (5) and higher isoprenologues (21), (24), and (27), followed by reductive elimination of p-tolylsulphonyl group, furnishes a stereoselective synthesis of all-trans-polyprenols (3), (23), (26), and decaprenol (1b).Solanesol (1a) was synthesised using trans-4-chloroprenyl acetate (29) instead of (7).
Hypertension treating agent containing polyprenyl alcohol
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, (2008/06/13)
This invention relates to a hypertension treating agent comprising a polyprenyl alcohol or an ester thereof of the general formula: STR1 wherein n represents an integer of 7-10 and A represents a group of the general formula: STR2 in which a and b each represent hydrogen or they may form a bond, or STR3 in which R represents hydrogen or --COR', R' being a saturated or unsaturated aliphatic hydrocarbon group of 1-17 carbon atoms; cyclohexyl group; unsubstituted phenyl group or phenyl group substituted with a halogen atom or a lower alkoxy group; (halogen atom-substituted phenoxy)-lower alkyl group; or pyridyl group.
