5400-82-8

Basic information

• Product Name: N,N-dimethylbenzylamine N-oxide
• Synonyms: N,N-dimethylbenzylamine N-oxide;Benzyldimethylamine oxide;Benzyloxylatodimethylaminium;N,N-Dimethylbenzenemethanamine oxide;N,N-DimethylbenzenemethanamineN-oxide;N,N-Dimethylbenzylamine oxide;N,N-dimethyl-1-phenylmethanamine oxide;N,N-dimethyl-1-phenyl-methanamine oxide
• CAS NO: 5400-82-8
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.20562
• EINECS: 226-443-1
• Mol File: 5400-82-8.mol
• Article Data: 28

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: N,N-dimethylbenzylamine N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dimethylbenzylamine N-oxide(5400-82-8)
• EPA Substance Registry System: N,N-dimethylbenzylamine N-oxide(5400-82-8)

Safety Data

• Hazardous Substances Data: 5400-82-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H13NO/c1-10(2,11)8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3

Upstream product

• 103-83-3 N,N'-dimethylbenzylamine 
• 76847-41-1 3-bromo-4,5-dihydro-5-hydroperoxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole 
• 72229-10-8 cis-3-bromo-4,5-dihydro-5-hydroperoxy-4,4-dimethyl-3,5-diphenyl-3H-pyrazole 
• 107743-45-3 C₁₇H₁₆⁽²⁾HBrN₂O₂ 
• 79075-90-4 4a-hydroperoxy-N⁵-ethyl-N³-methyl-1,5-dihydro-1-deazalumiflavin 
• 182943-76-6 3-hydroperoxy-3-phenyl-4,4,5,5-tetramethyl-1,2-dioxolane 
• 59587-26-7 4a-hydroperoxy-N⁵-ethyl-N³-methyllumiflavin 

Downstream Products

• 90524-35-9 C₁₅H₂₈NOSi⁽¹⁺⁾*CF₃O₃S^(1-) 
• 103-83-3 N,N'-dimethylbenzylamine 
• 81577-03-9 piperazine-2,3 diphenyl N,N-dimethyl trans 
• 81577-01-7 piperazine-2,3 diphenyl N,N-dimethyl cis 
• 100-52-7 benzaldehyde 
• 103-67-3 benzyl-methyl-amine 
• 83616-70-0 N,N-dimethylbenzylamine oxide-SbCl₅ 
• 13807-57-3 N-benzyl-N-methyl-(3-phenyl-2-propynyl)amine 
• 61802-83-3 N-methyl-N-benzylbenzamide 
• 14321-25-6 (N-benzyl-N-methylamino)acetonitrile 
• 827-36-1 2-(N,N-dimethylamino)-2-phenylacetonitrile 
• 35478-74-1 Dimethylamino-phenyl-methanesulfonic acid 
• 16938-30-0 O-benzyl-N,N-dimethyl-hydroxylamine 

Relevant articles and documents

Kinetics of acetonitrile-assisted oxidation of tertiary amines by hydrogen peroxide

The rate of oxidation of tertiary amines by aqueous hydrogen peroxide is increased in the presence of acetonitrile due to the formation of a reactive intermediate. The active oxidant, presumably peroxyacetimidic acid, was quantified by a photometric method. Activation parameters of the acetonitrile-assisted and non-assisted oxidations are given in the temperature range 20 to 40 °C. The increased rate of the assisted oxidation is explained by the low enthalpy of activation although the entropy of activation is more negative due to a highly ordered transition state.

Anti-tumor application of tocopheroxyl nitrogen oxide as HDAC (Histone Deacetylase) inhibitor

The invention discloses anti-tumor application of tocopheroxyl nitrogen oxide as an HDAC (Histone Deacetylase) inhibitor. A compound has a structural general formula as shown in a formula (I), and the compound has a potential inhibition effect on HDAC, so that more nitrogen and oxygen can be further provided for a ZBG (Zinc Binding Group), multi-length survey and the like can be carried out on a linker, structure modification can be carried out on the existing basis, and the functions of an inhibitor having good selectivity on HDAC subtype and other target points are expected to be found. According to the anti-tumor application disclosed by the invention, synthetic raw materials are relatively cheap, the technology is simple, the purity is higher, the cost is lower, and used reagents are all relatively safe. The compound is expected to be used as a novel HDAC inhibitor type anti-tumor medicine which is strong in selectivity, high in efficiency and low in toxicity.

2,2,2-Trifluoroacetophenone as an organocatalyst for the oxidation of tertiary amines and azines to N-oxides

A cheap, mild and environmentally friendly oxidation of tertiary amines and azines to the corresponding Noxides is reported by using polyfluoroalkyl ketones as efficient organocatalysts. 2,2,2-Trifluoroacetophenone was identified as the optimum catalyst for the oxidation of aliphatic tertiary amines and azines. This oxidation is chemoselective and proceeds in high-to-quantitative yields utilizing 10 mol% of the catalyst and H2O2 as the oxidant.