61802-83-3

Basic information

• Product Name: Benzamide, N-methyl-N-(phenylmethyl)-
• CAS NO: 61802-83-3
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 61802-83-3.mol
• Article Data: 96

Chemical Properties

• CAS DataBase Reference: Benzamide, N-methyl-N-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-methyl-N-(phenylmethyl)-(61802-83-3)
• EPA Substance Registry System: Benzamide, N-methyl-N-(phenylmethyl)-(61802-83-3)

Safety Data

• Hazardous Substances Data: 61802-83-3(Hazardous Substances Data)

Upstream product

• 103-83-3 N,N'-dimethylbenzylamine 
• 65-85-0 benzoic acid 
• 103-67-3 benzyl-methyl-amine 
• 91003-36-0 N-Benzyl-N-<(trimethylsilyl)methyl>benzamide 
• 102-05-6 N-methyldibenzylamine 
• 51643-97-1 2-(benzyl(N-methyl)amino)-2-phenylacetonitrile 
• 618-36-0 rac-methylbenzylamine 
• 100-51-6 benzyl alcohol 
• 17105-71-4 N-methyl-N-benzylformamide 
• 100-52-7 benzaldehyde 
• 591-50-4 iodobenzene 
• 199620-14-9 chromium⁽⁰⁾ hexacarbonyl 
• 614-45-9 tert-Butyl peroxybenzoate 
• 98-86-2 acetophenone 

Downstream Products

• 13901-76-3 dimethyl 1-methyl-2,5-diphenylpyrrole-3,4-dicarboxylate 
• 102-05-6 N-methyldibenzylamine 
• 1613045-62-7 (Z)-N-(1-(benzyl(methyl)amino)-3-oxo-1,3-diphenylprop-1-en-2-yl)-4-methylbenzenesulfonamide 
• 1613045-63-8 C₃₀H₂₈N₂O₃S 
• 1355027-03-0 N-benzyl-N-methyl-1-phenylbut-3-en-1-amine 
• 582-78-5 N-(4-methylphenyl)benzamide 
• 93-98-1 N-phenyl benzoyl amide 
• 16466-44-7 N-ethyl-N-phenylbenzamide 
• 614-30-2 N-methyl-N-phenyl-benzenemethanamine 
• 23825-32-3 N-benzoyl-N-methylbenzamide 
• 1448773-58-7 diethyl ((benzyl(methyl)amino)(phenyl)methyl)phosphonate 
• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 88070-48-8 N-methylbenzamide 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow

Phosphine-mediated deoxygenative nucleophilic substitutions, such as the Mitsunobu reaction, are of great importance in organic synthesis. However, the conventional protocols require stoichiometric oxidants to trigger the formation of the oxyphosphonium i

Direct Amidation of Esters by Ball Milling**

The direct mechanochemical amidation of esters by ball milling is described. The operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu and was used to prepare a large and diverse library of 78 amide structures with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochemical protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent.

DIVERSITY-ORIENTED SYNTHESIS OF N,N,O-TRISUBSTITUTED HYDROXYLAMINES FROM ALCOHOLS AND AMINES BY N-O BOND FORMATION

In one aspect, the disclosure relates to a method for the direct synthesis of complex N,N,O-trisubstituted hydroxylamines by N—O bond formation. In another aspect, the method can successfully be employed using a wide variety of commercially available alcohols and secondary amines and enables the construction of large fragment-based libraries of trisubstituted hydroxylamines for drug discovery purposes. Also disclosed are N,N,O-trisubstituted hydroxylamines having low basicity, high stability at ambient temperatures, and an inherent lack of reactivity towards acetylating and sulfonylating enzymes that confer mutagenicity on less-substituted hydroxylamines.