54001-18-2

Basic information

• Product Name: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE
• Synonyms: BUTTPARK 97\12-47;4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE;4-Methyl-2-phenyl-1,3-thiazole-5-carbonyl chloride ,97%;4-Methyl-2-phenyl-thiazole-5-carbonyl chloride;5-(Chlorocarbonyl)-4-methyl-2-phenyl-1,3-thiazole
• CAS NO: 54001-18-2
• Molecular Formula: C₁₁H₈ClNOS
• Molecular Weight: 237.71
• Mol File: 54001-18-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 122 °C
• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.6 °C
• Appearance: /
• Density: 1.319 g/cm³
• Vapor Pressure: 1.01E-05mmHg at 25°C
• Refractive Index: 1.609
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.62±0.10(Predicted)
• CAS DataBase Reference: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(54001-18-2)
• EPA Substance Registry System: 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBONYL CHLORIDE(54001-18-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: IRRITANT
• Hazardous Substances Data: 54001-18-2(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C11H8ClNOS/c1-7-9(10(12)14)15-11(13-7)8-5-3-2-4-6-8/h2-6H,1H3

Upstream product

• 2227-79-4 benzenecarbothioamide 
• 53715-64-3 4-methyl-2-phenyl-thiazole-5-carboxylic acid ethyl ester 
• 33763-20-1 4-methyl-2-(phenyl)-1,3-thiazol-5-carboxylic acid 

Downstream Products

• 69973-68-8 (4-methoxy-phenyl)-(4-methyl-2-phenyl-thiazol-5-yl)-methanone 
• 343322-20-3 2-methyl-2-[4-{[(4-methyl-2-phenyl-1,3-thiazol-5-ylcarbonyl)amino]methyl}phenoxy]propionic acid ethyl ester 
• 7520-95-8 2-bromo-1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1-ethanone 
• 1044873-06-4 N-(4-methyl-2-phenyl-1,3-thiazol-5-oyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 
• 1069135-25-6 C₁₁H₉NOS₂ 
• 33763-20-1 4-methyl-2-(phenyl)-1,3-thiazol-5-carboxylic acid 
• 1182328-96-6 C₃₃H₂₉ClFN₃O₃S₃ 
• 927672-33-1 4-methyl-2-phenyl-thiazole-5-carboxylic acid [2-(2,6-dioxo-piperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]methylamide 
• 69973-74-6 (4-bromomethyl-2-phenyl-thiazol-5-yl)-(4-methylsulfanyl-phenyl)-methanone 
• 69973-73-5 (4-bromomethyl-2-phenyl-thiazol-5-yl)-(4-methoxy-phenyl)-methanone 
• 69973-72-4 (4-bromomethyl-2-phenyl-thiazol-5-yl)-phenyl-methanone 
• 69973-82-6 2,6-diphenyl-selenolo[3,4-d]thiazole 
• 69973-77-9 2,6-diphenyl-thieno[3,4-d]thiazole 
• 69973-78-0 6-(4-methoxy-phenyl)-2-phenyl-thieno[3,4-d]thiazole 

Relevant articles and documents

Substituted 2-[(4-aminomethyl)phenoxy]-2-methylpropionic acid PPARα agonists. 1. Discovery of a novel series of potent HDLc raising agents

The peroxisome proliferator activated receptors PPARα, PPARγ, and PPARδ are ligand-activated transcription factors that play a key role in lipid homeostasis. The fibrates raise circulating levels of high-density lipoprotein cholesterol and lower levels of triglycerides in part through their activity as PPARα agonists; however, the low potency and restricted selectivity of the fibrates may limit their efficacy, and it would be desirable to develop more potent and selective PPARα agonists. Modification of the selective PPARδ agonist 1 (GW501516) so as to incorporate the 2-aryl-2-methylpropionic acid group of the fibrates led to a marked shift in potency and selectivity toward PPARα agonism. Optimization of the series gave 25a, which shows EC50 = 4 nM on PPARα and at least 500-fold selectivity versus PPARγ and PPARγ. Compound 25a (GW590735) has been progressed to clinical trials for the treatment of diseases of lipid imbalance.