69973-68-8

Upstream product

• 54001-18-2 4-methyl-2-phenyl-thiazole-5-carbonyl chloride 
• 100-66-3 methoxybenzene 
• 4023-80-7 1-(4-methoxyphenyl)butan-1,3-dione 
• 2227-79-4 benzenecarbothioamide 
• 55-21-0 benzamide 

Downstream Products

• 69973-78-0 6-(4-methoxy-phenyl)-2-phenyl-thieno[3,4-d]thiazole 
• 69973-83-7 6-(4-methoxy-phenyl)-2-phenyl-selenolo[3,4-d]thiazole 
• 69973-73-5 (4-bromomethyl-2-phenyl-thiazol-5-yl)-(4-methoxy-phenyl)-methanone 

Relevant academic research and scientific papers

An efficient, one-pot, regioselective synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles under solvent-free conditions

In this article, we present an efficient, one-pot regioselective approach towards the synthesis of 2-aryl/hetaryl-4-methyl-5-acylthiazoles obtained during the reaction of α-bromo-1,3-diketones generated in situ by triturating unsymmetrical 1,3-diketones with N-bromosuccinimide, with various thioamides under solvent-free conditions. This environmentally benign protocol showed large functional group tolerance, resulted in the exclusive formation of a single isomer, out of the two possible regioisomers in admirable yields. The structure of the isomeric thiazole was assigned unambiguously on the basis of multinuclear NMR [(1H-13C) HMBC, (1H-13C) HMQC, (1H-15N) HMBC] and X-ray crystallographic studies. The entire protocol is ecologically desirable as it employs no organic solvent.