54013-07-9

Basic information

• Product Name: 2-AMINO-5-METHOXYPYRAZINE
• Synonyms: 2-AMINO-5-METHOXYPYRAZINE;2-Pyrazinamine, 5-methoxy-;5-Methoxy-2-pyrazinamine;5-Methoxy-pyrazin-2-ylaMine
• CAS NO: 54013-07-9
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.13
• Mol File: 54013-07-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 110-111℃
• Boiling Point: 258.7±35.0℃ (760 Torr)
• Flash Point: 110.3±25.9℃
• Appearance: /
• Density: 1.224±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.74±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-METHOXYPYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-METHOXYPYRAZINE(54013-07-9)
• EPA Substance Registry System: 2-AMINO-5-METHOXYPYRAZINE(54013-07-9)

Safety Data

• Hazardous Substances Data: 54013-07-9(Hazardous Substances Data)

Usage

General Description

2-AMINO-5-METHOXYPYRAZINE is a chemical compound with a molecular formula C5H7N3O and a molecular weight of 125.13 g/mol. It is a heterocyclic aromatic compound with a pyrazine ring structure and contains an amino group and a methoxy group. 2-AMINO-5-METHOXYPYRAZINE has a strong, earthy aroma and is commonly used as a flavoring agent in the food industry. It is found in various foods and beverages, adding a roasted or smoky flavor. Additionally, it has been studied for its potential medical applications, such as its antimicrobial and anti-inflammatory properties.

InChI:InChI=1/C5H7N3O/c1-9-5-3-7-4(6)2-8-5/h2-3H,1H3,(H2,6,7)

Upstream product

• 124-41-4 sodium methylate 
• 33332-29-5 2-amino-5-chloropyrazine 
• 59489-71-3 5-amino-2-bromopyrazine 

Downstream Products

• 134510-06-8 2-hydroxy-5-methoxypyrazine 
• 1245214-62-3 2-ethyl-N-(5-methoxypyrazin-2-yl)-4-[4-(methylsulfonyl)phenoxy]-2H-indazole-6-carboxamide 
• 1020335-77-6 phenyl (5-methoxypyrazin-2-yl)carbamate 

Relevant articles and documents

Design and synthesis of a novel series of 4-heteroarylamino-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octanes as α7 nicotinic receptor agonists 2. Development of 4-heteroaryl SAR

Quinuclidine-containing spirooxazolines, as described in the previous report in this series, were demonstrated to have utility as α7 nicotinic acetylcholine receptor (α7 nAChR) partial agonists. In this work, the SAR of this chemotype was expanded to include an array of diazine heterocyclic substitutions. Many of the heterocyclic analogs were potent partial agonists of the α7 receptor, selective against other nicotinic receptors and the serotinergic 5HT3A receptor. (1′S,3′R,4′S)-N-(6-phenylpyrimidin-4-yl)-4H-1′-azaspiro[oxazole-5,3′-bicyclo[2.2.2]octan]-2-amine, a potent and selective α7 nAChR partial agonist, was demonstrated to improve cognition in the mouse novel object recognition (NOR) model of episodic memory.

THERAPEUTICALLY ACTIVE THIAZOLO-PYRIMIDINE DERIVATIVES

A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

COMPOUNDS AND THERAPEUTICAL USE THEREOF

Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.