54020-55-2Relevant articles and documents
Il-8 receptor anatagonists
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, (2008/06/13)
This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
Hydroxy diphenyl urea sulfonamides as IL-8 receptor antagonists
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, (2008/06/13)
Novell IL-8 compounds and methods of using them are provided.
α-Amino Acids as Chiral Educts for Asymmetric Products. The Synthesis of α'-Amino-α,β-ynones
Cupps, Thomas L.,Boutin, Raymond H.,Rapoport, Henry
, p. 3972 - 3979 (2007/10/02)
α-Amino acid isoxazolidides have been developed as educts for the preparation of optically pure α'-amino-α,β-ynones.The α-amino acids were first N-protected as their ethoxycarbonyl, tert-butoxycarbonyl, or phenylsulfonyl derivatives.The isoxazolidides then were formed by the simple, high yield acylation of isoxazolidine by in situ generated α-amino acid isobutyl carbonic anhydrides.Individual isoxazolidides of L-α-N-substituted alanine, phenylalanine, and methionine, when treated with lithium acetylide, lithium (trimethylsilyl)acetylide, or 1-hexynyllithium, gave high yields of the corresponding optically pure α,β-acetylenic ketones.
