540468-96-0

Basic information

• Product Name: (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol
• Synonyms: (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol;3-(Trifluoromethyl)-1-methyl-1H-pyrazole-4-methanol
• CAS NO: 540468-96-0
• Molecular Formula: C₆H₇F₃N₂O
• Molecular Weight: 180.1277896
• Mol File: 540468-96-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 226.4±35.0 °C(Predicted)
• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 13.49±0.10(Predicted)
• CAS DataBase Reference: (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol(540468-96-0)
• EPA Substance Registry System: (1-Methyl-3-(trifluoroMethyl)-1H-pyrazol-4-yl)Methanol(540468-96-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 540468-96-0(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow solid

Upstream product

• 111493-74-4 ethyl 3-(trifluoromethyl)-1-methyl-1H-pyrazole-4-carboxylate 
• 155377-19-8 ethyl 3-trifluoromethyl-1H-pyrazole-4-carboxylate 
• 113100-53-1 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid 

Downstream Products

• 128225-66-1 1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

ANTIDIABETIC SPIROCHROMAN COMPOUNDS

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

2-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-3-PHENYL PYRAZINES AND PYRIDINES AND 3-[4-(PYRAZOL-4-YLALKYL)PIPERAZIN-1-YL]-2-PHENYL PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS

The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine, persistent pain, and anxiety: where A and B are each independently C(H)= or N=, provided that at least one of A and B is -N=, n is 1-3, m is 0-3, and R14 are as defined herein.