540475-57-8

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 14760-51-1 2'(4-fluorophenyl)-11β,17α,21-trihydroxy-20-oxo-pregn-4-eno[3,2-c]pyrazole 
• 50-23-7 HYDROCORTISONE 
• 69607-31-4 2'-(4-fluorophenyl)-11β-hydroxy-17,20:20,21-bis(methylenedioxy)pregn-4-eno[3,2-c]pyrazole 

Downstream Products

• 1258527-91-1 C₂₈H₃₂FN₅O₃ 
• 1258527-71-7 C₃₉H₄₄FN₅O₄ 
• 1258525-87-9 C₃₅H₃₆FN₃O₃S₂ 
• 1258527-85-3 C₃₁H₃₅FN₄O₃ 
• 540475-59-0 2'-(4-fluorophenyl)-21-iodo-20-oxo-11β,17α-dihydroxy-pregn-4-eno[3,2-c]pyrazole 

Relevant academic research and scientific papers

Steroidal C-21 heteroaryl thioethers. Part 3: Pregn-4-eno-[3,2-c]pyrazole fused A ring modified steroids as selective glucocorticoid receptor modulators (dissociated steroids)

The introduction of A ring pyrazole modification to the hydrocortisone C-21 heteroaryl thioethers generated compounds with excellent transrepression potency (IL-8 inhibition) compared to their hydrocortisone analogs. However, the transcriptional transacti

NOVEL [3,2-c] HETEROARYL STEROIDS AS GLUCOCORTICOID RECEPTOR AGONISTS, COMPOSITIONS AND USES THEREOF

The present invention provides compounds of Formula (I), and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers, or isomers of said compounds), having the general structure: Formula (I) wherein L, R1, R2, R

Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors

Corticosteroids regulate a variety of essential physiological functions, such as mineral balance and stress. The great interest in these steroids, especially the glucocorticoids, stems from roles they are thought to play in neuropsychiatric disorders, suc