54049-23-9

Upstream product

• 123-30-8 4-amino-phenol 

Downstream Products

• 51642-26-3 2-nitro-4-azidophenol 
• 705934-28-7 4-[5-(4-Methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenol 
• 112723-89-4 5-hydroxy-2,3-diphenylindole 
• 91444-54-1 2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol 
• 198481-32-2 bazedoxifene 
• 869663-58-1 4-(5-amino-3-tert-butyl-pyrazol-1-yl)-phenol 

Relevant academic research and scientific papers

Regioselective synthesis of indoles via rhodium-catalyzed C-H activation directed by an in-situ generated redox-neutral group

A regioselective synthesis of indoles from arylhydrazine hydrochlorides with alkynes and diethyl ketone catalyzed by a rhodium complex is described. A possible mechanism involving an in-situ generated oxidizing directing group -N-Ni'CR1R2 assisted ortho-C-H activation and reductive elimination are proposed. The catalytic reaction is highly compatible with a wide range of functional arylhydrazines and alkynes. The reaction proceeds under mild reaction conditions and is atom-step economical.

METHODS OF PREPARINGBAZEDOXIFENE BY NEW INTERMEDIATES

The present invention relates to a method for manufacturing novel bazedoxifene or a pharmaceutically acceptable salt thereof. A manufacturing method according to the present invention can provide high purity and high yield of bazedoxifene, and is economical in terms of time and cost and eco-friendly due to a relatively simple manufacturing process, thereby being able to be usefully applied to mass production.COPYRIGHT KIPO 2020