869663-58-1

Basic information

• Product Name: Phenol, 4-[5-amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-
• CAS NO: 869663-58-1
• Molecular Formula: C13H17N3O
• Molecular Weight: 231.297
• Mol File: 869663-58-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Phenol, 4-[5-amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 4-[5-amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-(869663-58-1)
• EPA Substance Registry System: Phenol, 4-[5-amino-3-(1,1-dimethylethyl)-1H-pyrazol-1-yl]-(869663-58-1)

Safety Data

• Hazardous Substances Data: 869663-58-1(Hazardous Substances Data)

Upstream product

• 59997-51-2 trimethylacetylacetonitrile 
• 54049-23-9 4-hydroxyphenylhydrazine hydrochloride 
• 3471-32-7 4-Methoxyphenylhydrazine 
• 227623-26-9 3-tert-butyl-1-(4-methoxyphenyl)-1H-pyrazol-5-amine 

Downstream Products

• 1443248-12-1 5-tert-butyl-2-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-2H-pyrazol-3-ylamine 
• 876301-36-9 3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine 
• 1241507-55-0 3-tert-butyl-1-(4-(2-morpholinoethoxy) phenyl)-1H-pyrazol-5-amine 
• 1443248-15-4 (5-tert-butyl-2-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenyl}-2H-pyrazol-3-yl)-N,N-bis-carbamic acid 2,2,2-trichloro-ethyl ester 

Relevant articles and documents

POLYAROMATIC UREA DERIVATIVES AND THEIR USE IN THE TREATMENT OF MUSCLE DISEASES

The current invention provides urea derivatives, in particular compounds having the core structure heteroaryl-NH-CO-NH-aryl-O- heteroaryl, for use in treating, ameliorating, delaying, curing and/ or preventing a disease or condition associated with muscle cells and/or satellite cells, such as Duchenne muscular dystrophy, Becker muscular dystrophy, cachexia or sarcopenia.

KINASE INHIBITORS

Compounds of formula (I) or a pharmaceutically acceptable salt thereof: wherein R2, W, A, Y and R1 are as defined in the specification, are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.

PYRAZOLE P38 MAP KINASE INHIBITORS

There are provided inter alia compounds of formula (I): wherein R1, R2a, R2b, R3, R4, L, X, R5 and R6 are as defined in the description for use in the treatment of inflammatory diseases.