54049-92-2

Upstream product

• 3240-35-5 4-formyl-benzenesulfonamide 
• 77-78-1 dimethyl sulfate 
• 58804-18-5 4-hydroxymethyl-benzenesulfonic acid dimethylamide 
• 85822-16-8 4-formylbenzene-1-sulfonyl chloride 
• 124-40-3 dimethyl amine 
• 63877-94-1 4-cyano-N,N-dimethylbenzenesulfonamide 
• 49584-26-1 p-cyanobenzenesulfonyl chloride 
• 13736-22-6 sodium 4-carboxy-benzenesulfonate 

Downstream Products

• 439690-31-0 4-{[(6-tert-butylthieno[2,3-d]pyrimidin-4-yl)hydrazono]methyl}-N,N-dimethylbenzenesulfonamide 
• 1177251-30-7 4-[(1-benzyl-1H-tetrazol-5-yl)(4-cyclobutyl-1,4-diazepan-1-yl)methyl]-N,N-dimethylbenzenesulfonamide 
• 615581-36-7 {4-[3-(1,3-dioxolan-2-yl)propyl]phenylsulfonyl}(dimethyl)amine 
• 615581-40-3 5-{4-[(dimethylamino)sulfonyl]phenyl}pentan-2-ol 
• 615581-42-5 5-{4-[(dimethylamino)sulfonyl]phenyl}pentan-2-one 
• 615581-38-9 4-{4-[(dimethylamino)sulfonyl]phenyl}butanal 

Relevant academic research and scientific papers

BIOPROBES FOR LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel bioprobes which are capable of binding to certain amine oxidase enzymes. These bioprobes are useful in methods of detecting and determining the concentration of certain amine oxidase enzymes in a sample as well as in methods for the quantitative assessment of inhibition of certain amine oxidases.

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB—Utilizing a Reversible Covalent Tethering Approach

Protein-protein modulation has emerged as a proven approach to drug discovery. While significant progress has been gained in developing protein-protein interaction (PPI) inhibitors, the orthogonal approach of PPI stabilization lacks established methodologies for drug design. Here, we report the systematic ″bottom-up″ development of a reversible covalent PPI stabilizer. An imine bond was employed to anchor the stabilizer at the interface of the 14-3-3/p65 complex, leading to a molecular glue that elicited an 81-fold increase in complex stabilization. Utilizing protein crystallography and biophysical assays, we deconvoluted how chemical properties of a stabilizer translate to structural changes in the ternary 14-3-3/p65/molecular glue complex. Furthermore, we explore how this leads to high cooperativity and increased stability of the complex.

PROTEIN-PROTEIN INTERACTION STABILIZERS

Provided herein, inter alia, are stabilizers of protein-protein interactions and methods of identifying and using the same.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation and structure-activity relationships. Part 2

The design, synthesis and evaluation of novel thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as cyclin-dependent kinase 4 (CDK4) inhibitor are described. Focusing on the optimization of the heteroaryl moiety at the hydrazone with substituted phenyl group