5405-65-2Relevant academic research and scientific papers
Host dihydrofolate reductase (DHFR)-directed cycloguanil analogues endowed with activity against influenza virus and respiratory syncytial virus
Tonelli, Michele,Naesens, Lieve,Gazzarrini, Sabrina,Santucci, Matteo,Cichero, Elena,Tasso, Bruno,Moroni, Anna,Costi, Maria Paola,Loddo, Roberta
, p. 467 - 478 (2017)
We have identified a series of 1-aryl-4,6-diamino-1,2-dihydrotriazines, structurally related to the antimalarial drug cycloguanil, as new inhibitors of influenza A and B virus and respiratory syncytial virus (RSV) via targeting of the host dihydrofolate r
