540526-22-5Relevant academic research and scientific papers
Microwave enabled external carboxymethyl substituents in the ring-closing metathesis
Yang, Cangming,Murray, William V.,Wilson, Lawrence J.
, p. 1783 - 1786 (2003)
The ring-closing metathesis of diolefin substrates containing an external carboxymethyl substituent is presented. The reaction is enabled through microwave irradiation allowing greatly enhanced yields and conversion rates. The reaction results in the formation of carboxymethyl substituted dihydropyrroles, dihydrofurans, and cyclopentenes. In certain cases, pyrroles are formed through further in situ oxidation.
Practical one-pot sequential procedure for the preparation of N-arylated 3,4-disubstituted pyrroles from alkenes
Zhu, Rui,Xing, Lixin,Liu, Yantao,Deng, Fangkun,Wang, Xinyan,Hu, Yuefei
scheme or table, p. 3897 - 3901 (2009/04/07)
By using tBuONa and Cs2CO3 as a mixed base, van Leusen pyrrole synthesis and copper-catalyzed N-arylation of pyrrole proceeded sequentially in a single flask to give N-arylated 3,4-disubstituted pyrroles smoothly. Thus, a series of desired N-arylated pyrroles were prepared directly from the electron-deficient alkenes.
ACID SECRETION INHIBITOR
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Page/Page column 44-45, (2009/01/24)
The present invention provides a compound having a superior acid secretion inhibitory action, an antiulcer activity and the like. A proton pump inhibitor containing a compound represented by the formula (I) wherein ring A is a saturated or unsaturated 5- or 6-membered ring group optionally having, as a ring-constituting atom besides carbon atom, 1 to 4 hetero atoms selected from a nitrogen atom, an oxygen atom and a sulfur atom, ring-constituting atoms X1 and X2 are each a carbon atom or a nitrogen atom, a ring-constituting atom X3 is a carbon atom, a nitrogen atom, an oxygen atom or a sulfur atom, R1 is an optionally substituted aryl group or an optionally substituted heteroaryl group, R2 is an optionally substituted alkyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group, R3 is an aminomethyl group optionally substituted by 1 or 2 lower alkyl groups, which is a substituent on a ring-constituting atom other than X1, X2 and X3, and ring A optionally further has substituent(s) selected from a lower alkyl group, a halogen atom, a cyano group and an oxo group, or a salt thereof or a prodrug thereof.
