54056-66-5Relevant academic research and scientific papers
Penicillins
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, (2008/06/13)
Penicillins of the formula: SPC1 And their pharmaceutically acceptable nontoxic salts wherein R1 is hydrogen, halogen, lower alkyl, hydroxy, nitro or A--NH; A is EQU1 wherein R3 is hydrogen; lower alkyl; halo-(lower alkyl); cycloalkyl of 3 to 11 carbon atoms, unsubstituted or substituted by hydroxy or alkyl of 1 or 2 carbon atoms; cycloalkenyl of 3 to 11 carbon atoms; bicycloalkyl of up to 8 carbon atoms; bicycloalkenyl of up to 8 carbon atoms; aryl of 6 to 10 carbon atoms, unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl, nitro, amino, alkylsulphonyl of 1 to 4 carbon atoms, and methylenedioxy; azidoaryl of 6 to 10 carbon atoms, azido-(lower alkyl); amino; or thienyl; R4 is lower alkylamino or arylamino of 6 to 10 carbon atoms; B is a direct bond; CH2 ; S--CH2 ; CH=CH; or CO--NH--CH2 ; E is phenyl or phenyl or thenyl, substituted by hydroxy, azido, lower alkyl, lower alkoxy, lower alkylthio or chlorine; and C* is an asymmetric carbon atom, Are useful for their antibacterial activity against both Gram-positive and Gram-negative bacteria.
