54089-03-1

Upstream product

• 1129-66-4 5-Cyclohexyl-1-pentanol 
• 931-50-0 cyclohexylmagnesium bromide 
• 5962-88-9 5-cyclohexylvaleric acid 
• 111-24-0 1,5-dibromo-pentane 
• 2270-20-4 5-Phenylpentanoic acid 
• 108-86-1 bromobenzene 
• 5631-95-8 2,3-dichlorotetrahydro-2H-pyran 
• 17851-39-7 5-cyclohexyl-valeric acid ethyl ester 
• 13159-16-5 (E)-5-phenyl-4-penten-1-ol 

Downstream Products

• 919832-72-7 5-(iodopentyl) cyclohexane 
• 178670-96-7 1-Bromo-10-cyclohexyldecane 
• 1268525-99-0 3-((4-chlorophenyl)(5-cyclohexylpentyl)amino)-1-methylquinolinium iodide 
• 1268525-89-8 N-(4-chlorophenyl)-N-(5-cyclohexylpentyl)-quinolin-3-yl-amine 
• 1383710-80-2 10-chloro-7-(5-cyclohexyl-pentyl)-7H-indolo[2,3-c]-quinoline 
• 1383710-76-6 10-Chloro-7-(5-cyclohexyl-pentyl)-5-methyl-7H-indolo[2,3-c]quinolin-5-ium iodide 
• 951647-77-1 1-(5-cyclohexylpentyl)-3-(phenylamino)quinolinium iodide 
• 1310693-38-9 8-cyano-5-(5-cyclohexylpentyl)-1-methyl-5H-pyrido[3,2-b]indol-1-ium iodide 
• 1310693-37-8 5-(5-cyclohexylpentyl)-8-methoxy-1-methyl-5H-pyrido[3,2-b]indol-1-ium iodide 
• 1310693-36-7 5-(5-cyclohexylpentyl)-1-methyl-8-(methylthio)-5H-pyrido[3,2-b]indol-1-ium iodide 
• 1310693-35-6 5-(5-cyclohexylpentyl)-1,8-dimethyl-5H-pyrido[3,2-b]indol-1-ium iodide 

Relevant academic research and scientific papers

3-SUBSTITUTED QUINOLINIUM AND 7H-INDOLO[2,3-c]QUINOLINIUM SALTS AS NEW ANTIINFECTIVES

The present invention relates to quinolinium antiinfective agents in which the qunolinium nucleus is fused to an indole ring or the qunolinium nucleus is linked to a cyclic structure through an opened indole or a benzothiophene or benzofuran ring. The compound is further substituted with various substituent groups. The compounds are represented by formula (I), (II) and (III): Pharmaceutical compositions and methods of use are also included.

Identification of 3-phenylaminoquinolinium and 3-phenylaminopyridinium salts as new agents against opportunistic fungal pathogens

Previous studies on the indoloquinoline alkaloid, cryptolepine (2), revealed that it has antii-nfective properties among other activities. Using Structure-activity relationship (SAR) techniques, several ring-opened analogs of cryptolepine (3-phenylaminopyridinium and 3-phenylaminoquinolinium derivatives) were designed to improve the potency and lower the cytotoxicity shown by several of the precursor agents. Results indicate that these ring-opened analogs constitute new anti-infective agents with over a 100-fold potency and several fold lower cytotoxicity than cryptolepine from which they are derived.

Antifungal and antiparasitic indoloquinoline derivates

A compound having the formula: wherein: R is an electron withdrawing or electron donating moiety; R5 and R10 may be the same or different and are a straight or branched 1-5 carbon or heteroatom chain substituted terminally by a cycloalkyl or aromatic ring, or other structural isomer or complex thereof; n is the position of substitution of R; Z is N—R10, O, S, S═O, CH2 or C═O; y is 1-5 and Q is Z or NH, with the proviso that, where Z is NH, N—CH3, S or O and Rn is H, R5 may not be CH3; as well as quaternary ammonium salts thereof and their use as pharmacological compositions and for methods of treatment.

Anti-inflammatory furanones

New 5-hydroxy-2-furanone compounds having anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.

Heterocyclic ketone prostaglandin analogs

Prostaglandin analogs useful in treating thrombotic and vasospastic disease having the structural formula STR1 wherein: m is 1, 2, or 3; n is 0, 1, 2 or 3; R1 is hydrogen, alkyl, alkenyl, alkynyl, aralkyl, aryl cycloalkyl, cycloalkylalkyl, cycl