5962-88-9

Basic information

• Product Name: CYCLOHEXANEPENTANOIC ACID
• Synonyms: CYCLOHEXANEVALERIC ACID;CYCLOHEXANEPENTANOIC ACID;CYCLOHEXYLVALERIC ACID;5-CYCLOHEXYLVALERIC ACID;5-CYCLOHEXYLPENTANOIC ACID;AI3-14245;Cyclohexanepentanoic acid,5-Cyclohexylvaleric acid;Cyclohexanepentanoic acid 98%
• CAS NO: 5962-88-9
• Molecular Formula: C₁₁H₂₀O₂
• Molecular Weight: 184.28
• Mol File: 5962-88-9.mol

Chemical Properties

• Melting Point: 16-17 °C(lit.)
• Boiling Point: 126-127 °C0.5 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 0.96 g/mL at 25 °C(lit.)
• Vapor Pressure: 7.39E-05mmHg at 25°C
• Refractive Index: n20/D 1.4656(lit.)
• CAS DataBase Reference: CYCLOHEXANEPENTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLOHEXANEPENTANOIC ACID(5962-88-9)
• EPA Substance Registry System: CYCLOHEXANEPENTANOIC ACID(5962-88-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 5962-88-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cyclohexanepentanoic acid is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with specific therapeutic properties, contributing to the advancement of medical treatments.
Used in Chemical Synthesis:
In the chemical industry, Cyclohexanepentanoic acid is used as a key component in the synthesis of various chemicals and materials. Its versatile structure enables the creation of a wide range of products, from specialty chemicals to advanced materials with specific properties.
Used in Biotechnology:
Cyclohexanepentanoic acid is used as a growth medium for specific microorganisms, such as Pseudomonas oleovorans, which are involved in the production of polymers containing cyclohexyl units. This application highlights the potential of Cyclohexanepentanoic acid in the development of novel biotechnological processes and materials with diverse applications.

InChI:InChI=1/C11H20O2/c12-11(13)9-5-4-8-10-6-2-1-3-7-10/h10H,1-9H2,(H,12,13)

Upstream product

• 2270-20-4 5-Phenylpentanoic acid 
• 701-97-3 cyclohexanepropionic acid 
• 147936-56-9 3-cyclohexyl-1-iodopropane 
• 1124-63-6 3-cyclohexylpropan-1-ol 
• 110-83-8 cyclohexene 
• 91765-15-0 5-cyclohex-1-enyl-5-oxo-valeric acid methyl ester 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 28028-86-6 (E)-2-(3-phenylallylidene)malonic acid 
• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 875247-76-0 5-cyclohexylpentan-2-one 
• 591-80-0 pent-4-enoic acid 
• 110-82-7 cyclohexane 
• 100315-79-5 (3-cyclohexyl-propyl)-malonic acid 
• 60439-16-9 1-bromo-4-cyclohexylbutane 

Downstream Products

• 5693-80-1 5-cyclohexylpentanoyl chloride 
• 250681-40-4 N-[5-(5-cyclohexylvaleramido)-2-methylphenyl]-4-(diethylaminomethyl)benzamide 
• 6320-71-4 2-(4-cyclohexylbutyl)-3-hydroxy-1,4-naphthoquinone 

Relevant articles and documents

Palladium(II)-Catalyzed Enantioselective Arylation of Unbiased Methylene C(sp3)?H Bonds Enabled by a 2-Pyridinylisopropyl Auxiliary and Chiral Phosphoric Acids

Enantioselective functionalizations of unbiased methylene C(sp3)?H bonds of linear systems by metal insertion are intrinsically challenging and remain a largely unsolved problem. Herein, we report a palladium(II)-catalyzed enantioselective arylation of unbiased methylene β-C(sp3)?H bonds enabled by the combination of a strongly coordinating bidentate PIP auxiliary with a monodentate chiral phosphoric acid (CPA). The synergistic effect between the PIP auxiliary and the non-C2-symmetric CPA is crucial for effective stereocontrol. A broad range of aliphatic carboxylic acids and aryl bromides can be used, providing β-arylated aliphatic carboxylic acid derivatives in high yields (up to 96 %) with good enantioselectivities (up to 95:5 e.r.). Notably, this reaction also represents the first palladium(II)-catalyzed enantioselective C?H activation with less reactive and cost-effective aryl bromides as the arylating reagents. Mechanistic studies suggest that a single CPA is involved in the stereodetermining C?H palladation step.

DESIGN AND SYNTHESIS OF OPTIMIZED LIGANDS FOR PPAR

This invention provides new chemical entities useful for treating a variety of clinical disorders including those that areinfluenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5-adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

Unusual products from dirhodium tetraacetylate-catalyzed decomposition of diazoacetylcycloalkanes

Rh2(OAc)4-assisted decompositions of diazoacetylcycloalkanes are shown to yield cycloalkylacetic acids (Wolff rearrangement), unexpected cycloalkylcarboxylic acids and bicyclic ketones (intramolecular C-H bond insertion). Rh2(OCOF3)4-promoted reactions, on the other hand, have furnished bicyclic ketones and ketene dimers.

DEPLACEMENTS HOMOLYTIQUES INTRAMOLECULAIRES-I; ETUDE DE LA DECOMPOSITION DU PERPENTENE-4 OATE DE t-BUTYLE DANS LES CYCLANES. SYNTHESE DE CYCLOALKYL-5 PENTANOLIDES-4

The thermolysis of t-butyl-4-peroxypentenoate 1, in cyclohexane led to several compounds; the main product was 5-cyclohexyl-4-pentanolide (yield 35percent).Hypotheses are proposed to explain their formation.The lactone could be obtained by two different mechanisms: a concerted one and a two-step one (cyclohexyl radical addition to the double bond of the perester leading to a discrete radical followed by an intramolecular displacement of a t-butoxyl radical).The thermolysis of 1 has synthetic interest: several original 5-cycloalkyl-4-pentanolides have been obtained by this way.