5409-59-6

Basic information

• Product Name: (3E)-1,4-diphenylbut-3-en-2-one
• Synonyms: (3E)-1,4-Diphenylbut-3-en-2-one; 3-buten-2-one, 1,4-diphenyl-, (3E)-
• CAS NO: 5409-59-6
• Molecular Formula: C₁₆H₁₄O
• Molecular Weight: 222.2818
• Mol File: 5409-59-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 380.1°C at 760 mmHg
• Flash Point: 145°C
• Density: 1.085g/cm³
• Vapor Pressure: 5.57E-06mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: (3E)-1,4-diphenylbut-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3E)-1,4-diphenylbut-3-en-2-one(5409-59-6)
• EPA Substance Registry System: (3E)-1,4-diphenylbut-3-en-2-one(5409-59-6)

Safety Data

• Hazardous Substances Data: 5409-59-6(Hazardous Substances Data)

Usage

General Description

(3E)-1,4-diphenylbut-3-en-2-one, also known as chalcone, is a chemical compound classified as a benzylideneacetophenone. It is a yellow solid with a molecular formula C15H12O and a molecular weight of 208.25 g/mol. Chalcone is widely used in organic synthesis and pharmaceutical research due to its interesting chemical properties and potential biological activities. It is known to exhibit antioxidant, anti-inflammatory, and anticancer activities, making it a potential therapeutic agent for various diseases. Additionally, chalcone has been studied for its potential as a fluorescent dye and as a precursor for the synthesis of various pharmaceutical compounds.

Upstream product

• 110-91-8 morpholine 
• 536-74-3 phenylacetylene 
• 100-52-7 benzaldehyde 
• 103-79-7 1-phenyl-acetone 
• 102-92-1 cinnamoyl chloride 
• 131973-46-1 benzyltetrabutyl stiborane 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 100-52-7 benzaldehyde 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 350-92-5 1,1,1-Trifluoro-3-phenylpropan-2-one 
• 1309977-12-5 C₂₁H₂₃N₃O 
• 117535-82-7 2-(4-bromoanilino)-5,6-dihydro-3,6-diphenyl-4H-thiopyran-4-one 
• 117535-81-6 5,6-dihydro-3,6-diphenyl-2-(2-methylanilino)-4H-thiopyran-4-one 
• 117535-80-5 2-anilino-5,6-dihydro-3,6-diphenyl-4H-thiopyran-4-one 
• 81603-26-1 2-ethoxy-2-benzyl-4-phenylchroman 
• 117535-88-3 5-anilino-1,4-diphenyl-5-methylthio-3-oxo-1,4-pentanediene 
• 80331-37-9 3-(3-Oxo-1,4-diphenyl-butyl)-benzaldehyde 
• 81603-20-5 4-phenyl-2-methylchroman-2-ol 
• 102705-68-0 1,4,4-triphenylbut-3-en-2-one 
• 87351-02-8 1,4,4-triphenyl-butan-2-one 
• 52452-40-1 4-Ethoxy-2-oxo-3,6-diphenyl-cyclohex-3-enecarboxylic acid ethyl ester 

Relevant articles and documents

2:1 versus 1:1 Coupling of Alkylacetylenes with Secondary Amines: Selectivity Switching in 8-Quinolinolato Rhodium Catalysis

Both 2:1 and 1:1 couplings of alkylacetylenes with secondary amines were achieved using 8-quinolinolato rhodium catalysts and CsF. The 2:1/1:1 selectivity was switched by choosing the reaction solvent. In DMA, an unprecedented 2:1 coupling reaction of alkylacetylenes with amines proceeded to give 2-aminodiene products. One-pot 2:1 coupling/reduction provided rapid access to various allylamines, while one-pot coupling/hydrolysis gave enones as products. In toluene, anti-Markovnikov hydroamination occurred under relatively mild conditions to give 1:1 coupling products.

Synthesis of (E)-stilbenes and (E,E)-1,4-diphenylbuta-1,3-diene promoted by boron trifluoride-diethyl ether complex

An efficient, simple, and practical method has been de-veloped to regioselectively synthesize (E)-stilbenes and (E,E)-1,4diphenylbuta-1,3-diene in good to excellent yields in the presence of boron trifluoride-diethyl ether complex as a catalyst in a short reaction (30-60 s) at room temperature. Georg Thieme Verlag Stuttgart.

Enamine synthesis using the Horner-Wittig reaction. Part 2. New acyl anion equivalents derived from (aminomethyl)diphenylphosphine oxides

Using the Horner-Wittig reagents (1-morpholino-alkyl)diphenylphosphine oxides (1), aromatic as well as aliphatic α,β-unsaturated aldehydes can be converted into the morpholino enamines of their respective homologous phenyl, ethyl and styryl ketones.These enamines can be easily converted into the corresponding ketones by mild, acid-catalyzed hydrolysis.The usefulness of these phosphine oxides as acyl anion equivalents is further demonstrated by the synthesis of dihydrojasmone and of (Z)-6-henicosen-11-one.