5409-59-6

Usage

Uses

Used in Pharmaceutical Research:
Chalcone is utilized as an active pharmaceutical ingredient due to its demonstrated antioxidant, anti-inflammatory, and anticancer activities. Its potential therapeutic value makes it a candidate for the treatment of various diseases, particularly those related to oxidative stress and inflammation.
Used in Organic Synthesis:
In the field of organic synthesis, chalcone serves as a key intermediate and a valuable building block for the creation of more complex molecules. Its unique structure allows for further functionalization and modification, contributing to the development of novel compounds with specific applications.
Used as a Fluorescent Dye:
Chalcone's potential as a fluorescent dye has been explored, capitalizing on its ability to emit light upon excitation. This characteristic can be harnessed in various analytical and diagnostic applications where the detection and visualization of specific molecules or biological processes are required.
Used as a Precursor for Pharmaceutical Compounds:
Chalcone is recognized as a precursor in the synthesis of a variety of pharmaceutical compounds. Its versatility in chemical reactions enables the production of diverse molecules with different therapeutic properties, expanding the scope of available treatments for various medical conditions.

Upstream product

• 100-52-7 benzaldehyde 
• 103-79-7 1-phenyl-acetone 
• 102-92-1 cinnamoyl chloride 
• 131973-46-1 benzyltetrabutyl stiborane 
• 7647-01-0 hydrogenchloride 
• 110-91-8 morpholine 
• 536-74-3 phenylacetylene 

Downstream Products

• 37985-17-4 1,4-diphenyl-2-butanone 
• 16797-37-8 4-(2,5-diphenyl-thiophen-3-yl)-morpholine 
• 65966-91-8 ((E)-1-Benzyl-1-hydroxy-3-phenyl-allyl)-phosphonic acid dimethyl ester 
• 52452-40-1 4-Ethoxy-2-oxo-3,6-diphenyl-cyclohex-3-enecarboxylic acid ethyl ester 
• 102705-68-0 1,4,4-triphenylbut-3-en-2-one 
• 87351-02-8 1,4,4-triphenyl-butan-2-one 
• 81603-20-5 4-phenyl-2-methylchroman-2-ol 
• 80331-37-9 3-(3-Oxo-1,4-diphenyl-butyl)-benzaldehyde 
• 117535-88-3 5-anilino-1,4-diphenyl-5-methylthio-3-oxo-1,4-pentanediene 
• 100-52-7 benzaldehyde 
• 81603-26-1 2-ethoxy-2-benzyl-4-phenylchroman 
• 117535-80-5 2-anilino-5,6-dihydro-3,6-diphenyl-4H-thiopyran-4-one 
• 117535-81-6 5,6-dihydro-3,6-diphenyl-2-(2-methylanilino)-4H-thiopyran-4-one 
• 117535-82-7 2-(4-bromoanilino)-5,6-dihydro-3,6-diphenyl-4H-thiopyran-4-one 

Relevant academic research and scientific papers

2:1 versus 1:1 Coupling of Alkylacetylenes with Secondary Amines: Selectivity Switching in 8-Quinolinolato Rhodium Catalysis

Both 2:1 and 1:1 couplings of alkylacetylenes with secondary amines were achieved using 8-quinolinolato rhodium catalysts and CsF. The 2:1/1:1 selectivity was switched by choosing the reaction solvent. In DMA, an unprecedented 2:1 coupling reaction of alkylacetylenes with amines proceeded to give 2-aminodiene products. One-pot 2:1 coupling/reduction provided rapid access to various allylamines, while one-pot coupling/hydrolysis gave enones as products. In toluene, anti-Markovnikov hydroamination occurred under relatively mild conditions to give 1:1 coupling products.

H2SO4-promoted synthesis of (E)-stilbenes from substituted phenylacetones and substituted benzaldehydes through tandem aldol-Grob reaction

Stilbene derivates (stilbenoids) are present in plants and show a wide range of biological activities and potential therapeutic value. In continuation of our natural product synthesis program, an efficient, simple, and practical method has been developed to regioselectively synthesize (E)-stilbenes using H2SO4 as a catalyst in a short time (30-60 s) at room temperature in good to excellent yields.

Synthesis of (E)-stilbenes and (E,E)-1,4-diphenylbuta-1,3-diene promoted by boron trifluoride-diethyl ether complex

An efficient, simple, and practical method has been de-veloped to regioselectively synthesize (E)-stilbenes and (E,E)-1,4diphenylbuta-1,3-diene in good to excellent yields in the presence of boron trifluoride-diethyl ether complex as a catalyst in a short reaction (30-60 s) at room temperature. Georg Thieme Verlag Stuttgart.

Enamine synthesis using the Horner-Wittig reaction. Part 2. New acyl anion equivalents derived from (aminomethyl)diphenylphosphine oxides

Using the Horner-Wittig reagents (1-morpholino-alkyl)diphenylphosphine oxides (1), aromatic as well as aliphatic α,β-unsaturated aldehydes can be converted into the morpholino enamines of their respective homologous phenyl, ethyl and styryl ketones.These enamines can be easily converted into the corresponding ketones by mild, acid-catalyzed hydrolysis.The usefulness of these phosphine oxides as acyl anion equivalents is further demonstrated by the synthesis of dihydrojasmone and of (Z)-6-henicosen-11-one.