5410-49-1

Upstream product

• 5555-32-8 N-(cyanomethyl)-4-nitrobenzamide 
• 7512-77-8 ethyl 2-(4-nitrobenzamido)acetate 
• 122-04-3 4-nitro-benzoyl chloride 
• 598-41-4 H-Gly-NH₂ 
• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 1668-10-6 glycinamide hydrochloride 

Downstream Products

• 46319-19-1 N-(4-amino-benzoyl)-glycine amide 

Relevant academic research and scientific papers

New charge-bearing amino acid residues that promote β-sheet secondary structure

Proteinogenic amino acid residues that promote β-sheet secondary structure are hydrophobic (e.g., Ile or Val) or only moderately polar (e.g., Thr). The design of peptides intended to display β-sheet secondary structure in water typically requires one set of residues to ensure conformational stability and an orthogonal set, with charged side chains, to ensure aqueous solubility and discourage self-association. Here we describe new amino acids that manifest substantial β-sheet propensity, by virtue of β-branching, and also bear an ionizable group in the side chain.

Stabilizing and destabilizing effects of phenylalanine → F 5-phenylalanine mutations on the folding of a small protein

We report a systematic evaluation of phenylalanine-to-pentafluorophenylalanine (Phe → F5-Phe) mutants for the 35-residue chicken villin headpiece subdomain (c-VHP), the hydrophobic core of which features a cluster of three Phe side chains (residues 6, 10, and 17). Phe → F5-Phe mutations are interesting because aryl-perfluoroaryl interactions of optimal geometry are intrinsically more favorable than aryl-aryl interactions and because perfluoroaryl units are more hydrophobic than are analogous aryl units. One mutant, Phe-10 → F5-Phe, provides enhanced tertiary structural stability relative to the native sequence. The other six mutants analyzed caused a decrease in stability. Copyright

Substituent effect on acidity of substituted 2-(4-nitrobenzoylamino)alkanamidesin methanol-dimethyl sulfoxide mixtures

The dissociation constants of substituted 2-(4-nitrobenzoylamino)alkanamides, N-[2-(4-nitrobenzoylamino)aikanoyl]pyrrolidines, and N-alkyl-4-nitrobenzamides have been measured spectrophotometrically in 60 and 80% v/v DMSO. The pKA values of these N-acids are discussed from the point of view of substituents at the acetamide a-carbon atom.