54109-03-4

Basic information

• Product Name: 5-Chloro-1-(3H)-Isobenzofuranone
• Synonyms: 5-Chloro-1-(3H)-Isobenzofuranone;1(3H)-Isobenzofuranone, 5-chloro-;5-Chlorophthalide;NSC 49581
• CAS NO: 54109-03-4
• Molecular Formula: C₈H₅ClO₂
• Molecular Weight: 168.5771
• Mol File: 54109-03-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 154-155℃
• Boiling Point: 363.9°Cat760mmHg
• Flash Point: 205.9°C
• Appearance: /
• Density: 1.428g/cm³
• Vapor Pressure: 1.74E-05mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Chloro-1-(3H)-Isobenzofuranone(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1-(3H)-Isobenzofuranone(54109-03-4)
• EPA Substance Registry System: 5-Chloro-1-(3H)-Isobenzofuranone(54109-03-4)

Safety Data

• Hazardous Substances Data: 54109-03-4(Hazardous Substances Data)

Usage

Uses

5-Chloro-1(3H)-isobenzofuranone acts as a reagent in the synthesis of naphthylpiperazine with dual activity as 5-HTID antagonists and 5-HT reuptake inhibitors.

InChI:InChI=1/C8H5ClO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3H,4H2

Upstream product

• 615-60-1 4-chloro-1,2-dimethylbenzene 
• 608-23-1 3-chloro-o-xylene 
• 6833-15-4 4-chlorobenzanilide 
• 118-45-6 4-chlorophthalic anhydride 

Downstream Products

• 95834-48-3 4-chloro-2-(4'-dimethylaminophenyl)indan-1,3-dione 
• 98216-82-1 5-chloro-1,3-dihydroisobenzofuran-1-ol 
• 82104-74-3 1-oxo-1,3-dihydro-isobenzofuran-5-carbonitrile 
• 95834-46-1 2,2'-bis<5-chloro-2-(4''-dimethylaminophenyl)indan-1,3-dione> 
• 4657-56-1 4-chloro-2-formylbenzoic acid 
• 871502-91-9 4-chloro-2-bis(5-methyl-2-furyl)methylbenzoic acid 

Relevant articles and documents

Method for removing impurities from oxidation products

Disclosed is a method for removing impurities from products derived from oxidation of an ortho-dialkylaromatic compound which comprises at least one step selected from the group consisting of extraction of an aqueous solution comprising aromatic dicarboxylic acid product with an organic solvent and extraction of an organic solution comprising aromatic anhydride product with an aqueous bicarbonate solution for a time period insufficient to allow hydrolysis of anhydride to acid.

Potential GABAB Receptor Antagonists. III Folded Baclofen Analogues Based on Phthalide

Possible analogues of baclofen, 3-aminomethyl-5-chloro-, 3-aminomethyl-6-chloro- and 3-aminomethyl-5,6-dichloro-isobenzofuran-1(3H)-one, have been prepared for evaluation as antispasticity agents.The corresponding 3-hydroxyisobenzofuran-1(3H)-one was reac