5411-50-7

Basic information

• Product Name: NSC10978
• Synonyms: NSC10978;1,2-dibroMo-4-nitrobenzen;2-DIBROMO-4-NITROBENZENE
• CAS NO: 5411-50-7
• Molecular Formula: C₆H₃Br₂NO₂
• Molecular Weight: 280.903
• Mol File: 5411-50-7.mol

Chemical Properties

• Melting Point: 58.5°C
• Boiling Point: 296°C (rough estimate)
• Appearance: /
• Density: 2.2414 (rough estimate)
• Refractive Index: 1.6400 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: NSC10978(CAS DataBase Reference)
• NIST Chemistry Reference: NSC10978(5411-50-7)
• EPA Substance Registry System: NSC10978(5411-50-7)

Safety Data

• Hazardous Substances Data: 5411-50-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
NSC10978 is used as an anticancer agent for its demonstrated ability to inhibit the growth of various cancer cell types. It is particularly effective against colorectal, breast, and lung cancer cells, where it induces cell cycle arrest and apoptosis, thereby disrupting the proliferation and survival of these cells.
Used in Cancer Research:
In the field of cancer research, NSC10978 is utilized as a tool to study the mechanisms of action of serine/threonine protein kinase inhibitors. Its non-specific nature allows researchers to explore the effects of inhibiting multiple enzymes involved in cancer cell growth and survival, providing insights into potential therapeutic targets and strategies for cancer treatment.
Used in Drug Development:
NSC10978 is employed in the development of novel cancer therapeutics. Its potential as a protein kinase inhibitor makes it a valuable compound for the creation of new drugs that could target and disrupt the pathways that cancer cells rely on for growth and survival, offering a new avenue for the treatment of various types of cancer.
Used in Combination Therapy:
NSC10978 is also considered for use in combination therapies for cancer treatment. Its ability to induce cell cycle arrest and apoptosis in cancer cells suggests that it could be used alongside other chemotherapeutic agents to enhance their efficacy and overcome resistance in cancer treatment. Further studies are needed to explore these potential synergistic effects and to optimize the use of NSC10978 in combination with other treatments.

Upstream product

• 583-53-9 2,3-dibromobenzene 
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• 610-27-5 4-nitrophthalic acid 
• 615-36-1 2-bromoaniline 
• 577-19-5 2-nitrophenyl bromide 
• 586-78-7 para-nitrophenyl bromide 
• 10403-47-1 2-bromo 5-nitroaniline 
• 106-95-6 allyl bromide 
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Downstream Products

• 5197-28-4 2-bromo-4-nitroanisole 
• 58244-42-1 2-bromo-1-ethoxy-4-nitrobenzene 
• 603-78-1 2,3-dibromobenzoic acid 
• 96558-80-4 1,2-dibromo-3,5-dinitrobenzene 
• 54558-18-8 1,2-dinitro-4,5-dibromobenzene 
• 20391-88-2 2-bromo-4-nitro-thiophenol 
• 615-55-4 3,4-dibromoaniline 
• 13296-94-1 2-bromo-4-nitroaniline 
• 767354-42-7 N,N'-bis-(2-bromo-4-nitro-phenyl)-ethylenediamine 
• 64230-23-5 2-bromo-4-nitro-N,N-dimethylaniline 
• 58291-59-1 2-Bromo-1-(4-chloro-phenylsulfanyl)-4-nitro-benzene 
• 121866-20-4 1-(2-bromo-4-nitrophenyl)heptyne 
• 24108-97-2 3,4-dibromoacetanilide 
• 20330-65-8 N-(4-heptylphenyl)acetamide 

Relevant articles and documents

meta-Nitration of Arenes Bearing ortho/para Directing Group(s) Using C?H Borylation

Herein, we report the meta-nitration of arenes bearing ortho/para directing group(s) using the iridium-catalyzed C?H borylation reaction followed by a newly developed copper(II)-catalyzed transformation of the crude aryl pinacol boronate esters into the corresponding nitroarenes in a one-pot fashion. This protocol allows the synthesis of meta-nitrated arenes that are tedious to prepare or require multistep synthesis using the existing methods. The reaction tolerates a wide array of ortho/para-directing groups, such as ?F, ?Cl, ?Br, ?CH3, ?Et, ?iPr ?OCH3, and ?OCF3. It also provides regioselective access to the nitro derivatives of π-electron-deficient heterocycles, such as pyridine and quinoline derivatives. The application of this method is demonstrated in the late-stage modification of complex molecules and also in the gram-scale preparation of an intermediate en route to the FDA-approved drug Nilotinib. Finally, we have shown that the nitro product obtained by this strategy can also be directly converted to the aniline or hindered amine through Baran's amination protocol.

PROCESS FOR THE PREPARATION OF ORGANIC HALIDES

The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Site-specific cleavage of nucleic acids by photoreactive conjugates

A process of forming a double strand cleavage in DNA includes providing a reaction mixture containing double stranded DNA having a break in a first strand defining a target site in a second strand. The method continues by adding to the reaction mixture a

Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone (GnRH) receptor

Antagonism of the gonadotropin releasing hormone (GnRH) receptor has resulted in positive clinical results in reproductive tissue disorders such as endometriosis and prostate cancer. Following the recent discovery of orally active GnRH antagonists based on a 4-piperazinylbenzimidazole template, we sought to investigate the properties of heterocyclic isosteres of the benzimidazole template. We report here the synthesis and biological activity of eight novel scaffolds, including imidazopyridines, benzothiazoles and benzoxazoles. The 2-(4-tert-butylphenyl)-8-(piperazin-1-yl)imidazo[1,2-a]pyridine ring system was shown to have nanomolar binding potency at the human and rat GnRH receptors as well as functional antagonism in vitro. Additional structure-activity relationships within this series are reported along with a pharmacokinetic comparison to the benzimidazole-based lead molecule.

Benzofused N-substituted cyclic enediynes: Activation and DNA-cleavage potential

The effect of electron withdrawal on the reactivity of N-substituted cyclic enediynes has been studied. These were synthesized via an intramolecular Mitsunobu reaction. The electron withdrawing effect of the nitro groups or the positive charge on the free

Electrochemical fluorination of aromatic compounds in anhydrous HF

Electrochemical fluorination of anisole furnished 2- and 4-fluoroanisoles in a 3:1 ratio, guaiacol, and 4,4′-dimethoxydiphenyl ether. Phenylacetonitrile alongside the fluorination in the ring suffered the transformation of the cyano group into a trifluoromethyl. 4-Bromobenzamide was fluorinated to a high conversion mostly in the ring to afford predominantly 4-bromo-3,3,6,6-tetrafluoro-1,4-cyclohexadienecarboxamide. 4-Bromonitrobenzene in a low yield gave 4-bromofluoronitrobenzene and 3,4-dibromofluoronitrobenzene. 3-Bromo-nitrobenzene and 1,4-dichlorobenzene did not undergo fluorination. In the course of the electrolysis of the 4-bromobenzamide and 4-bromonitrobenzene in anhydrous HF apart the fluorination occurred also the bromination of the substrates. Pleiades Publishing, Inc. 2006.

Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor

The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.

Lysine-enediyne conjugates as photochemically triggered DNA double-strand cleavage agents

Statistical analysis of DNA-photocleavage by two types of lysine-enediyne conjugates confirms that more double-strand breaks are produced than can be accounted for by coincident single-strand breaks. The Royal Society of Chemistry 2005.

Aromatic allylation via diazotization: Metal-free C-C bond formation

A new method for the synthesis of allyl aromatic compounds not involving any metal-containing reagent or catalyst has been developed. Arylamines substituted with a large number of different substituents were converted via diazotizative deamination with tert-butyl nitrite in allyl bromide and acetonitrile to the corresponding allyl aromatic compounds. The allylation reaction was found to be suitable for larger scale synthesis due to short reaction times, a nonextractive workup, and robustness toward moisture, air, and type of solvent.