64230-23-5

Usage

Uses

Used in Organic Synthesis:
2-bromo-N,N-dimethyl-4-nitroaniline is used as a reagent in organic synthesis for its ability to participate in various chemical reactions, facilitating the creation of a range of organic compounds.
Used in Dye Production:
In the dye industry, 2-bromo-N,N-dimethyl-4-nitroaniline is used as a precursor or intermediate in the synthesis of dyes, contributing to the development of colorants for different applications.
Used in Pharmaceutical Manufacturing:
2-bromo-N,N-dimethyl-4-nitroaniline is also utilized in the pharmaceutical sector, where it serves as a building block in the synthesis of various pharmaceuticals, potentially leading to the development of new drugs.
Used in Research:
2-bromo-N,N-dimethyl-4-nitroaniline is employed in research settings to study its biological and toxicological effects, which can provide insights into its potential applications and risks in various fields.

Upstream product

• 121-69-7 N,N-dimethyl-aniline 
• 10403-47-1 2-bromo 5-nitroaniline 
• 615-36-1 2-bromoaniline 
• 16588-26-4 3-bromo-4-chloronitrobenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 701-45-1 2-bromo-1-fluoro-4-nitrobenzene 
• 128-08-5 N-Bromosuccinimide 
• 100-23-2 N,N-Dimethyl-4-nitroaniline 
• 5411-50-7 3,4-dibromonitrobenzene 
• 124-40-3 dimethyl amine 

Downstream Products

• 860444-64-0 3-Brom-4-dimethylamino-anilin 
• 100709-22-6 trans-3-Brom-4-dimethylamino-azobenzol 
• 107753-78-6 ZAFIRLUKAST 
• 6911-88-2 (2-bromo-4-nitro-phenyl)-methyl-amine 
• 860533-10-4 2-bromo-N-methyl-4-nitro-N-nitroso-aniline 

Relevant academic research and scientific papers

Catalyst and Additive-Free Direct Amidation/Halogenation of Tertiary Arylamines with N-haloimide/amides

An approach has been developed for the amidation (halogenation) of tertiary arylamines by electrophilic activation using N-haloimide/amides. Several control experiments have been performed, and the coupling reaction outcomes indicated that the N-haloimide/amide brings three major functions, including electrophilic activation, aromatic halogenation and nucleophilic nitrogen sources. This cascade reaction features simple manipulation, requires no additional catalyst, oxidant or additives, and is performed under mild conditions. (Figure presented.).

Continuous flow nucleophilic aromatic substitution with dimethylamine generated in situ by decomposition of DMF

A safe, practical, and scalable continuous flow protocol for the in situ generation of dimethylamine from DMF followed by nucleophilic aromatic substitution of a broad range of aromatic and heteroaromatic halides is reported.

Alkyl Nitrite-Metal Halide Deamination Reactions. 7. Synthetic Coupling of Electrophilic Bromination with Substitutive Deamination for Selective Synthesis of Multiply Brominated Aromatic Compounds from Arylamines

Aromatic amines undergo substitution with copper(II)bromide that is in competition with substitutive deamination when these reactions are performed with tert-butyl nitrite.Except for the exceptionally reactive 4-substituted 1-aminonaphthalenes,which undergo selective bromine substitution at the 1- and 2-positions in relatively high isolated yields,rates for oxidative bromination and substitutive deamination are not sufficiently different that selective multiple bromination can be achieved.Oxidative bromination of N,N-dimethylaniline by copper(II)bromide occurs with partial dealkylation,and nitration products are observed from reactions performed with copper(II)bromide and tert-butyl nitrite.Implications of these results for the successful utilization of copper(II)bromide/tert-butyl nitrite combinations in substitutive deamination reactions of aromatic amines are discussed.Multiply brominated aromatic compounds are produced from aromatic amines in high yield through treatment of the aromatic amine with the combination of molecular bromine and catalytic quantities of copper(II)bromide and,following a normally brief time delay,with tert-butyl nitrite.All unsubstituted aromatic ring positions ortho and para to the amino group,as well as the position of the amino group,are substituted by bromine.The only observed byproducts from use of this procedure (usually 2percent yield) are the partially brominated benzene derivatives.