54114-47-5Relevant academic research and scientific papers
Reactions of benzazole-2-thiones with 3,5-di-tert-butyl-4-hydroxybenzyl acetate
Tagasheva,Gataullina,Zaripova,Bukharov,Nugumanova,Deberdeev,Voronina, Yu. K.
, p. 22 - 28 (2017)
The benzylation of benzothiazole(oxazole, imidazole)-2-thiones with 3,5-di-tert-butyl-4-hydroxybenzyl acetate involves either the sulfur or nitrogen atom depending on the reaction conditions. The S- and N-benzylation products of benzazole-2-thiones are kinetically and thermodynamically controlled products, respectively. The use of 3,5-di-tert-butyl-4-hydroxy-benzyl acetate allows sterically hindered hydroxybenzyl derivatives of benzаzole-2-thiones to be generally synthesized under milder conditions than in known methods of their synthesis.
Antiradical activity of benzazole-2-thiones
Gataullina,Mogilevtseva,Nugumanova,Bukharov,Tagasheva,Deberdeev, R. Ya.
, p. 1919 - 1923 (2017/10/27)
Reaction of benzoxazole-2-thione with 3,5-di-tert-butyl-4-hydroxybenzylacetate in methanol affords S-(3,5-di-tert-butyl-4-hydroxybenzyl)-2-mercaptobenzoxazole as the major product. Antiradical activity of S- and N-3,5-di-tert-butyl-4-hydroxybenzyl derivatives of benzothiazole(oxazole, imidazole)-2-thione with respect to 2,2-diphenyl-1-picrylhydrazyl is varies widely. S-Benzyl derivatives exhibit higher reactivity at 30°C.
