54149-78-9

Upstream product

• 21661-84-7 2,2-di-morpholin-4-yl-1-p-tolyl-ethanone 
• 64-17-5 ethanol 
• 122-51-0 orthoformic acid triethyl ester 
• 122-00-9 para-methylacetophenone 
• 1075-47-4 4-methylphenylglyoxal 
• 25234-85-9 1,1-diethoxybut-3-yn-2-one 
• 78-79-5 isoprene 
• 4974-59-8 2,2-dichloro-4'-methylacetophenone 

Downstream Products

• 930278-34-5 (R)-2,2-diethoxy-1-(4 methylphenyl)ethanol 
• 66476-17-3 1-Methyl-4-(1,1,2,2-tetraethoxy-ethyl)-benzene 

Relevant academic research and scientific papers

Diels-Alder reactions with 1,1-diethoxybut-3-yn-2-one and some 1,1-diethoxy-5-hydroxyalk-3-yn-2-ones and their acetates

The title compounds were reacted with a few conjugated dienes at room temperature and above. The alcohols were unreactive, but the other ynones reacted at a reasonable rate. Conceivably, the expected cyclohexa-1,4-diene adducts were formed, but they were unstable and aromatized to the corresponding benzene derivatives, which were isolated in low to excellent yield.

Direct asymmetric reductive amination of α-keto acetals: A platform for synthesizing diverse α-functionalized amines

We report an efficient and straightforward method to synthesize enantio-enriched N-unprotected α-amino acetals via ruthenium-catalyzed direct asymmetric reductive amination. The α-amino acetal products are versatile and valuable platform molecules that can be converted to the corresponding α-amino acids, amino alcohols, and other derivatives by convenient transformations.

Green synthesis of 2, 2-dialkoxy acetophenone derivative

The invention provides green synthesis of a 2, 2-dialkoxy acetophenone derivative (1), and the structure of the 2, 2-dialkoxy acetophenone derivative (1) is shown as follows, wherein R is alkyl, and R1 is one or more of alkyl, halogen, alkoxy, N, N-dialkylamine or benzoring. According to the method, the 2, 2-dichloroacetophenone derivative, alcohol and alkali are taken as raw materials and are subject to heating and stirring to obtain a target product 2, filtering is performed after the reaction is completed, filtrate is concentrated, and a high-yield and high-purity product can be obtained. The method has the advantages of simple operation, few byproducts, and no generation of any toxic or environmentally harmful substances in the reaction. A new synthesis method is provided for the target product 1.

Synergistic Catalysis of Se and Cu for the Activation of α-H of Methyl Ketones with Molecular Oxygen/Alcohol to Produce α-Keto Acetals?

Selenium and copper synergistically catalyzed the oxidation/alkoxylation of methyl ketones to synthesize α-keto acetals directly. Using O2 as oxidant and alcohol as solvent and alkoxylation reagent, the reaction is practical from industrial viewpoint. Mechanistic studies revealed that copper promoted the oxidation of organoselenium intermediates with O2 to allow the key rearrangement and selenoxide syn-elimination regenerating the catalytically active organoselenium species.

One-pot synthesis of α-ketoacetals from aryl methyl ketones in the presence of selenous acid catalyzed by boron trifluoride etherate

A simple and efficient one-pot preparation of α-ketoacetals from substituted acetophenones and triethylorthoformate in the presence of H2SeO3 and BF3·Et2O as catalyst has been developed. The desired products are obtained in good yields by a simple protocol involving neat and mild reaction conditions. The present methodology provides an attractive alternative method for the preparation of α-ketoacetal derivatives.

Oxygen-containing titanocenes, and the use thereof

Titanocenes of the formula I STR1 in which R1 are cyclopentadienyl? groups and R2 and R3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by an acyloxy group are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.

Titanocenes, the use thereof, and n-substituted fluoroanilines

Titanocenes containing two 5-membered cyclodienyl gropus, for example cyclopentadienyl, and one or two 6-membered carbocyclic or 5- or 6-membered heterocyclic aromatic rings which are substituted by a fluorine atom in at least one of the two ortho-positions to the titanium-carbon bond and contain, as further substituents, a substituted amino radical, are suitable as photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds.

Titanocenes, the use thereof, and N-substituted pyrroles

Titanocenes containing two 5-membered cyclodienyl groups, for example cyclopentadienyl, and one or two 6-membered carbocyclic or 5- or 6-membered heterocyclic aromatic rings which are substituted by a fluorine atom in at least one of the two ortho-positions to the titanium-carbon bond and contain, as a further substituent, unsubstituted or substituted 1-pyrryl, are suitable as photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds.

Novel nitrogen-containing titanocenes, and the use thereof

Titanocenes of the formula I STR1 in which R1 are cyclopentadienyl? groups and R2 and R3 are aromatic radicals which are substituted in both ortho-positions by fluorine and, in addition, are substituted by a pyrrylalkyl group, amidoalkyl group or imidoalkyl group, are suitable as photoinitiators for the photopolymerization of ethylenically unsaturated compounds.