5415-72-5Relevant academic research and scientific papers
Design, Synthesis, and Antifungal Activity of Sulfoximine Derivatives Containing Nitroguanidine Moieties
Li, Hongsen,Li, Ya,Liu, Yuan,Shao, Qun,Xiao, Yulong,Xie, Yonghai,Zhao, Linjing
, (2022/02/16)
To discover novel pesticide candidates, a series of sulfoximine derivatives were designed and synthesized via the oxidation coupling reaction of sulfides and N-alkyl nitroguanidines. The compounds were evaluated for their antifungal activity against six phytopathogenic fungi. Most of them exhibited a broad spectrum of fungicidal activity in vitro. Compound 8IV-b displayed good fungicidal activity against Sclerotinia sclerotiorum, Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Phytophthora capsici, with EC50 value of 12.82, 12.50, 17.25, 31.08, and 30.11 mg/L, respectively. In addition, compounds 8III-c and 8IV-e had EC50 values of 22.23 and 20.67 mg/L against P. capsic, which were significantly better than that of the commercial procymidone (118.15 mg/L). Strikingly, 8IV-d exhibited satisfactory fungicidal activity against B. cinerea, which was comparable to control procymidone in terms of their EC50 values (7.42 versus 10.83 mg/L), and the bioassays in vivo further confirmed that 8IV-d possessed potent protective effect against B. cinerea at 200 mg/L (72.2 %). These present findings will facilitate the design and development of novel potent fungicides.
Nitroguanidine compound and preparation and application thereof
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Paragraph 0033-0035; 0054-0055, (2020/04/02)
The invention relates to a nitroguanidine compound and preparation and application thereof. The nitroguanidine compound is a compound with a structure as shown in a general formula (I) which is described in the specification, or a pharmaceutically acceptable salt, enantiomer, diastereoisomer, tautomer, solvate, polymorphic substance or prodrug thereof. In the general formula (I), R1 is one selected from the group consisting of C1-C8 saturated or unsaturated aliphatic group, a benzyl group, a substituted benzyl group and a substituted pyridylmethyl group; and R2 is one selected from the group consisting of a C1-C8 saturated or unsaturated aliphatic group, a phenyl group, a substituted phenyl group and a substituted pyridyl group. Compared with the prior art, the nitroguanidine compound disclosed by the invention has a relatively good prevention effect on agricultural fungal diseases such as fusarium, gibberella, stemphylium solani, phytophthora, pythium aphanidermatum, botrytis cinerea,sclerotinia sclerotiorum and rhizoctonia solani, and can be used as a potential plant bactericide.
Substituted nitro and cyanoguanidines and their use of increasing crop yields
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, (2008/06/13)
Novel substituted phenyl and benzyl nitroguanidine and phenyl and benzyl cyanoguanidine compounds. Methods for increasing crop yield, inhibiting lodging of graminaceous crops, and inducing cytokinin-like responses in crop plants with said novel guanidine
