54167-67-8Relevant academic research and scientific papers
Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride
Xian, Liang,Ma, Cui-Ting,Ouyang, Ying-Gen,Di, Jia-Qi,Zhang, Zhan-Hui
, (2020)
An eco-friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one-pot, three-component coupling reaction of commercially available aldehydes, alkynes, and indazole3/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.
Green synthesis and characterization of silver nanoparticles (Ag NPs) from extract of plant Radix Puerariae: An efficient and recyclable catalyst for the construction of pyrimido[1,2-b]indazole derivatives under solvent-free conditions
Balwe, Sandip Gangadhar,Shinde, Vijay Vilas,Rokade, Ashish A.,Park, Seong Soo,Jeong, Yeon Tae
, p. 121 - 126 (2017)
We have developed a green and environmentally friendly approach for the synthesis of silver nanoparticles (Ag NPs) using Radix Puerariae plant extract via a novel chemical route. The prepared Ag NPs has been characterized by TEM, XRD, SEM, DLS, EDX, and UV–Vis. Further, catalytic application of this fascinating nanomaterial has been utilized in the synthesis of biologically important pyrimido[1,2-b]indazole derivatives via one-pot three-component coupling reaction between aldehydes, alkynes and amines with excellent yields under solvent-free conditions. After completion of the catalytic reaction, the Ag NPs could be easily recovered and reused for four times without significant loss in its catalytic activity.
A metal-free regioselective multicomponent approach for the synthesis of free radical scavenging pyrimido-fused indazoles and their fluorescence studies
Palaniraja, Jeyakannu,Roopan, Selvaraj Mohana,Rayalu, G. Mokesh,Al-Dhabi, Naif Abdullah,Arasu, Mariadhas Valan
, (2016/12/03)
This study deals with a new and efficient metal-free regioselective synthesis of pyrimido-fused indazoles with nitrogen ring junction motifs. We have developed a metal-free domino type reaction between 3-aminoindazole, aryl aldehydes and aceotophenones in the presence of KOH/DMF that leads to pyrimido[1,2-b]indazole analogues. Response Surface Methodology (RSM) coupled with a Box-Behnken design (BBD) were utilized for exploring the effect of base used (A), temperature of reaction (B) and (C), reaction time. This approach can allow access to a variety of pyrimidoindazole fluorophores and related compounds. The compound N,N-dimethyl-4-(2-phenylpyrimido[1,2-b]indazol-4-yl)aniline (4e) displays the maximum fluorescence intensity at 518 nm and shows a fluorescence quantum yield of 0.068. The synthesized pyramido-fused indazoles have been evaluated for their free radical scavenging activity and compound 4f showed good antioxidant activity.
One-pot synthesis of highly functionalized pyrimido[1,2-b]indazoles via 6-endo-dig cyclization
Palaniraja, Jeyakannu,Roopan, Selvaraj Mohana,Rayalu, G. Mokesh
, p. 24610 - 24616 (2016/03/15)
An efficient synthesis of nitrogen ring junction pyrimido-indazoles has been developed. This is a metal catalyzed transformation that proceeds via A3 coupling reaction between 1H-indazol-3-amine, aromatic aldehydes and alkynes, which undergoes
