5417-84-5 Usage
General Description
6-Ethylmercaptopurine, also known as 6-Mercaptopurine (6-MP), is a synthetic pharmaceutical compound used in the treatment of acute leukemia and inflammatory bowel disease. It is an analog of the purine base hypoxanthine and acts as a purine antagonist. 6-Ethylmercaptopurine works by inhibiting the synthesis of DNA and RNA, thereby preventing the proliferation of cancer cells and reducing inflammation in the intestines. It is metabolized in the body to form active metabolites that interfere with the synthesis of nucleic acids in rapidly dividing cells. However, 6-Ethylmercaptopurine can also have toxic effects on the bone marrow and liver, and can increase the risk of infection. Close monitoring of blood cell counts and liver function is necessary during treatment with this medication.
Check Digit Verification of cas no
The CAS Registry Mumber 5417-84-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,4,1 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5417-84:
(6*5)+(5*4)+(4*1)+(3*7)+(2*8)+(1*4)=95
95 % 10 = 5
So 5417-84-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N4S/c1-2-12-7-5-6(9-3-8-5)10-4-11-7/h3-5H,2H2,1H3
5417-84-5Relevant articles and documents
Pd/PTABS: Low-Temperature Thioetherification of Chloro(hetero)arenes
Bandaru, Siva Sankar Murthy,Bhilare, Shatrughn,Cardozo, Jesvita,Chrysochos, Nicolas,Schulzke, Carola,Sanghvi, Yogesh S.,Gunturu, Krishna Chaitanya,Kapdi, Anant R.
, p. 8921 - 8940 (2019/07/08)
The thioetherification of heteroaryl chlorides is an essential synthetic methodology that provides access to bioactive drugs and agrochemicals. Due to their (actual or potential) industrial importance, the development of efficient and low-temperature protocols for accessing these compounds is a requirement for economic and ecologic reasons. A particular highly effective catalytic protocol using the Pd/PTABS system at only 50 °C was developed accordingly. The coupling between chloroheteroarenes and a variety of less reactive arylthiols and alkylthiols was carried out with a high efficiency. Heteroarenes of commercial relevance such as purines and pyrimidines were also found to be useful substrates for the reported transformation. The commercial drug Imuran (azathioprine) was synthesized as an example, and its preparation could be optimized. DFT studies were performed to understand the electronic effects of the tested ligands on the catalytic reaction.
