5650-20-4

Basic information

• Product Name: 3,6,9,12-tetraoxatetradecan-1-ol
• Synonyms: 3,6,9,12-tetraoxatetradecan-1-ol;tetraethylene glycol monoethyl ether;Einecs 227-090-6;500Mg x 1, 1g x 1, 5g x 1
• CAS NO: 5650-20-4
• Molecular Formula: C₁₀H₂₂O₅
• Molecular Weight: 222.27868
• EINECS: 227-090-6
• Mol File: 5650-20-4.mol

Chemical Properties

• Boiling Point: 302.2°Cat760mmHg
• Flash Point: 136.6°C
• Appearance: /
• Density: 1.026g/cm³
• Vapor Pressure: 9.75E-05mmHg at 25°C
• Refractive Index: 1.438
• PKA: 14.36±0.10(Predicted)
• CAS DataBase Reference: 3,6,9,12-tetraoxatetradecan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6,9,12-tetraoxatetradecan-1-ol(5650-20-4)
• EPA Substance Registry System: 3,6,9,12-tetraoxatetradecan-1-ol(5650-20-4)

Safety Data

• Hazardous Substances Data: 5650-20-4(Hazardous Substances Data)

Usage

Uses

Used in Paint and Coating Industry:
3,6,9,12-Tetraoxatetradecan-1-ol is used as a surfactant for enhancing the stability and performance of paints and coatings. Its ability to emulsify and disperse other substances contributes to the creation of high-quality products with improved durability and finish.
Used in Cleaning Products:
In the cleaning products industry, 3,6,9,12-Tetraoxatetradecan-1-ol is utilized as a surfactant to improve the cleaning efficiency of various formulations. Its emulsifying and dispersing properties help in breaking down and removing dirt and stains effectively.
Used as a Solvent:
3,6,9,12-Tetraoxatetradecan-1-ol is employed as a solvent in certain chemical processes due to its capacity to dissolve a wide range of substances, facilitating reactions and improving the overall efficiency of the processes.
Used as a Wetting Agent:
In some applications, 3,6,9,12-Tetraoxatetradecan-1-ol serves as a wetting agent, which helps in the uniform spreading of liquids on surfaces. This property is particularly useful in agricultural, textile, and paper industries, where even distribution of treatments is crucial for optimal results.

InChI:InChI=1/C10H22O5/c1-2-12-5-6-14-9-10-15-8-7-13-4-3-11/h11H,2-10H2,1H3

Upstream product

• 75-21-8 oxirane 
• 64-17-5 ethanol 
• 111-90-0 ethoxyethoxyethanol 
• 141-43-5 ethanolamine 
• 60558-75-0 (2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethene 
• 112-60-7 Tetraethylene glycol 
• 75-03-6 ethyl iodide 
• 41771-35-1 1-[2-(ethoxy)ethoxy]-2-chloroethane 
• 111-46-6 diethylene glycol 
• 74-96-4 ethyl bromide 
• 54176-27-1 2-(2-ethoxyethoxy)ethyl tosylate 

Downstream Products

• 70068-56-3 1,2-Bis-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-4-vinyl-benzene 
• 70069-03-3 1-[3,4-Bis-(2-{2-[2-(2-ethoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-phenyl]-ethanol 
• 70069-02-2 3,4-Bis-(3,6,9,12-tetraoxatetradecyloxy)-acetophenon 
• 62921-76-0 2,5,8,11-tetraoxatridecan-13-ol tosylate 
• 75427-84-8 3-Benzyloxypropylenbis(3,6,9,12-tetraoxatetradecanoat) 
• 75427-85-9 2-Benzyloxy-3-(3,6,9-trioxadecanoyloxy)propyl-3,6,9,12-tetraoxatetradecanoat 
• 850143-45-2 4-(2-(2-(2-(2-ethoxyethoxy)ethoxy)ethoxy)ethoxy)phenylacetamidoxime 
• 5650-19-1 3,6,9,12-Tetraoxatetradecansaeure 

Relevant articles and documents

Synthesis and biological characterization of 1-methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole derivatives as muscarinic agonists for the treatment of neurological disorders

Muscarinic agonists might be useful in the treatment of neurological disorders, including Alzheimer's disease, schizophrenia, chronic pain, and drug abuse. Previous studies identified a series of bis-1,2,5-thiadiazole derivatives of 1,2,5,6-tetrahydropyridine with high activity and selectivity for muscarinic receptors. To develop compounds with improved central nervous system penetration, several new derivatives were synthesized and characterized for muscarinic receptor binding and activity. One ligand (11) exhibited agonist activity at M1, M2, and M4 receptors, a selectivity profile suggesting potential utility in the treatment of schizophrenia.

Inhibition of secretory phospholipase A2. 2-Synthesis and structure-activity relationship studies of 4,5-dihydro-3-(4-tetradecyloxybenzyl) -1,2,4-4H-oxadiazol-5-one (PMS1062) derivatives specific for group II enzyme

We have recently reported the discovery of a series of specific inhibitors of human group IIA phospholipase A2 (hGIIA PLA2) to display promising in vitro and in vivo properties. Here we describe the influence of different structural modifications on the specificity and potency against hGIIA PLA2 versus porcine group IB PLA2. The SAR results, as well as the log P and pKa values of oxadiazolone determined in this work, provide important information towards the comprehension of the mode of action of this kind of compounds.

Formation of macrocyclic ethers by free radical cyclization: Effects of chain length, substituents, and solvents

Free radical reduction by tributylstannane of w-iodopolyoxaalkyl acrylates derived from tri-, tetra-, penta-, hexa-, and heptaethylene glycols gives mixtures of uncyclized reduction products and macrocyclic ethers formed by endo cyclization. The rate constants for cyclization of the intermediate radicals at 80 °C in benzene were determined under carefully defined conditions to be 15 × 104,13 ×104,5.1 × 104,10 × 104 and 3.6 × 104 s-1, for formation of the 12-, 15-, 18-, 21- and 24-membered rings, respectively. These values indicate that the presence of oxygen atoms in the chains increases the rate by a factor of 10-30 by comparison with the previously reported cyclization of alkenyl species. The rate constants at 80 °C in benzene and the endo/exo ratio for reductive cyclizations of the methacrylate, crotonate, cinnamate, maleate, and fumarate esters of 8-iodo-3,6-dioxaoctanol have been determined. The reduction of the 8-iodo-3,6-dioxaoctyl acrylate in solvents of varying polarity indicated that the cyclization rate has a relatively low solvent dependence.

Veretherungen von Diolen, Triolen und Hydroxycarbonsaeurederivaten ueber Thallium(I)-alkoholate. Eine neue Variante der Williamson-Reaktion

The etherifications listed in tables 1 and 2 are achieved by converting hydroxy-derivatives, which contain additional oxygen functions, into thallium(I) alkoxides with thallium ethoxide, and treatment with haloalkanes.The scope and limitations of the method are discussed.

Hydrophilic Lipids

The new triesters of glycerol 1-8 with different oligoethylene glycol carboxylic acids ("hydrophilic lipids") have been synthesized and their complexation with alkali and alkaline earth metal cations has been investigated.