54187-93-8

Usage

Uses

Used in Pharmaceutical Industry:
Ethane, 1-bromo-2-(methylthio)is used as a reactant in the preparation of pantolactams, which are androgen receptor antagonists. These antagonists play a crucial role in the development of pharmaceuticals targeting androgen-dependent conditions, such as prostate cancer and other hormone-sensitive disorders. Ethane, 1-bromo-2-(methylthio)-'s unique structure allows for the formation of pantolactams through a series of chemical reactions, contributing to the advancement of medical treatments for these conditions.

Upstream product

• 5271-38-5 2-methylmercapto-ethanol 
• 74-93-1 methylthiol 
• 106-93-4 ethylene dibromide 

Downstream Products

• 5344-19-4 dithiocarbonic acid O-ethyl ester-S-(2-methylsulfanyl-ethyl ester) 
• 876511-09-0 (+)-4-methylsulfanyl-1.2-diphenyl-butanone-⁽¹⁾ 
• 20144-13-2 2-Benzoyl-4-methylmercapto-buttersaeure-aethylester 
• 20144-12-1 1,1-Dibenzoyl-3-methylmercapto-propan 
• 5271-38-5 2-methylmercapto-ethanol 
• 21281-74-3 2-hydroxyethyl methyl sulfoxide 
• 66559-07-7 2-(o-Formyl-phenoxy)-aethyl-methylsulfid 
• 16523-02-7 1-bromo-2-(methylsulfonyl)ethane 
• 1342746-15-9 2-(methylthio)-N-(2-morpholinoethyl)ethanamine 

Relevant academic research and scientific papers

Novel functionalized ionic liquid with a sulfur atom in the aliphatic side chain of the pyrrolidinium cation

A novel ionic liquid, never reported in literature until now, was properly designed, synthesized and preliminary investigated. This material was prepared combining the N-methylpyrrolidinium cation (PYR1(2S1))+, exhibiting a sulfur atom in the alkyl side chain, with the bis(trifluoromethanesulfonyl)imide anion, (TFSI)-, to be addressed as safer electrolyte component for sulfur-based battery systems. The presence of sulfur within the cation side chain was found to prevent the crystallization of the ionic liquid even in the presence of lithium salt. Cyclic voltammetries have clearly indicated that Li+ cation exhibits good mobility and is reversibly plated/stripped in PYR1(2S1)TFSI-LiTFSI electrolytes with high efficiency.

Compound as IRAK inhibitor

The present invention relates to a compound as an IRAK inhibitor, and specifically provides a compound, or a cis-trans isomer, an optical isomer or a raceme thereof, or a pharmaceutically acceptable salt thereof, or a prodrug thereof, or a deuterated derivative thereof, or a hydrate thereof, or a solvate thereof, wherein the compound has a structure represented by the following formula I. The compound provided by the invention has an effective inhibition effect on IRAK, so that the compound has a treatment effect on IRAK-related diseases.

Difluoro- and trifluoro diazoalkanes-complementary approaches in batch and flow and their application in cycloaddition reactions

Herein we report on applications of fluorinated diazoalkanes in cycloaddition reactions, with the emphasis on studying subtle differences between diverse fluorinated diazo compounds. These differences led to two major synthetic protocols in batch and flow that allow the safe and scalable synthesis of fluoroalkyl-, sulfone-substituted pyrazolines.

Air-Stable NNS (ENENES) Ligands and Their Well-Defined Ruthenium and Iridium Complexes for Molecular Catalysis

We introduce ENENES, a new family of air-stable and low-cost NNS ligands bearing NH functionalities of the general formula E(CH2)mNH(CH2)nSR, where E is selected from -NC4H8O, -NC4H8, or -N(CH3)2, m and n = 2 and/or 3, and R = Ph, Bn, Me, or SR (part of a thiophenyl fragment). The preparation and characterization of more than 15 examples of well-defined Ru and Ir complexes supported by these ligands that are relevant to bifunctional metal-ligand M/NH molecular catalysis are reported. Reactions of NNS ligands with suitable Ru or Ir precursors afford rich and diverse solid-state and solution chemistries, producing monometallic molecules as well as bimetallics in which the ligand coordinates to the metal via either bidentate (κ2[N,N'] or κ2[N',S]) or tridentate (κ3[N,N',S]) binding modes, depending on the basicity of the sulfur atom, CH2 chain length (m or n parameter), or identity of the transition metal. In the case of Ir, ligands bearing benzyl substituents lead to unprecedented κ4[N,N',S,C]-tetradentate core-structure complexes of the type [IrIIIHCl{κ4(N,N',S,C)-ligand}], resulting from ortho-metalation via C-H oxidative addition. Fourteen of these Ru and Ir complexes have been crystallographically characterized. Air- and moisture-stable complexes of the type trans-[RuIICl2{κ3[N,N',S]-ligand}(L)] (L = PPh3, PCy3, DMSO), and others, effect the selective hydrogenation of methyl trifluoroacetate into the important synthon trifluoroacetaldehyde methyl hemiacetal in basic methanol under relatively mild conditions (35-40 °C, 25 bar H2) with reasonable turnover numbers (i.e., > 1000), whereas the air-stable Ir monohydride complexes [IrIIIHCl{κ4(N,N',S,C)-ligand}] exhibit excellent catalytic activities and high chemoselectivity for the same reaction, reaching turnover numbers of >10 000.

POLYDENTATE LIGANDS AND THEIR COMPLEXES FOR MOLECULAR CATALYSIS

The present invention relates generally to novel achiral and chiral sulfur-, nitrogen- and phosphorus-containing ligands, designated as NNS-type, P(0)NS-type, PNS-type, SNNS-type, SNNP(0)-type, or SNNP-type polydentate ligands and transition metal complexes of these ligands. The catalysts derived from these ligands and transition metal complexes may be used in a wide range of catalytic reactions, including hydrogenation and transfer hydrogenation of unsaturated organic compounds, dehydrogenation of alcohols and boranes, various dehydrogenative couplings, and other catalytic transformations.