5421-01-2

Basic information

• Product Name: cyclopentyl 4-methoxybenzoate
• Synonyms: Cyclopentyl 4-methoxybenzoate
• CAS NO: 5421-01-2
• Molecular Formula: C₁₃H₁₆O₃
• Molecular Weight: 220.2643
• Mol File: 5421-01-2.mol

Chemical Properties

• Boiling Point: 331°C at 760 mmHg
• Flash Point: 136.6°C
• Density: 1.12g/cm³
• Vapor Pressure: 0.00016mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: cyclopentyl 4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: cyclopentyl 4-methoxybenzoate(5421-01-2)
• EPA Substance Registry System: cyclopentyl 4-methoxybenzoate(5421-01-2)

Safety Data

• Hazardous Substances Data: 5421-01-2(Hazardous Substances Data)

Upstream product

• 142-29-0 cyclopentene 
• 6343-26-6 1-(4-Methoxybenzoyl)pyrrolidine-2,5-dione 
• 63076-51-7 cyclopentane boronic acid 
• 104-93-8 p-methylanizole 
• 96-41-3 Cyclopentanol 
• 123-11-5 4-methoxy-benzaldehyde 
• 1879-16-9 1-methoxy-4-methylsulfanyl-benzene 
• 201230-82-2 carbon monoxide 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 3400-22-4 4-methoxy-N-methylbenzamide 
• 137-43-9 Cyclopentyl bromide 
• 100-09-4 4-methoxybenzoic acid 

Relevant articles and documents

Electro-Oxidative Selective Esterification of Methylarenes and Benzaldehydes

A mild and green electro-oxidative protocol to construct aromatic esters from methylarenes and alcohols is herein reported. Importantly, the reaction is free of metals, chemical oxidants, bases, acids, and operates at room temperature. Moreover, the design of the electrolyte was found critical for the oxidation state and structure of the coupling products, a rarely documented effect. This electro-oxidative coupling process also displays exceptional tolerance of many fragile easily oxidized functional groups such as hydroxy, aldehyde, olefin, alkyne, as well as neighboring benzylic positions. The enantiomeric enrichment of some chiral alcohols is moreover preserved during this electro-oxidative coupling reaction, making it overall a promising synthetic tool.

Hydroesterification and difunctionalization of olefins with N-hydroxyphthalimide esters

Irradiation of aryl esters of N-hydroxyphthalimides in the presence of unactivated olefins promotes a mild and regioselective hydroesterification. Optimal results are obtained with the aid of fac-Ir(dFppy)3 in CH2Cl2. Terminal and 1,1-disubstituted olefins provide primary esters, and trisubstituted olefins provide secondary esters. The anti-Markovnikov selectivity is consistent with alkyl radical intermediates, which are also indicated by the formation of cyclized products from dienes. Monoacylated diols are formed from trisubstituted and tetrasubstituted olefins in the presence of water.

Transition-Metal-Free DMAP-Mediated Aromatic Esterification of Amides with Organoboronic Acids

A new, transition-metal-free, effective method for aromatic esterification of amides with organoboronic acids has been developed. A wide range of benzoate derivatives were obtained with yields ranging from moderate to good. The catalytic reaction shows a broad substrate scope and excellent functional group tolerance. Conceptually, DMAP mediates the reaction and is crucial for this transformation.

Palladium-Catalyzed Alkoxycarbonylation of Arylsulfoniums

Alkoxycarbonylation of arylsulfoniums has been developed with the aid of a catalytic amount of a palladium-Xantphos complex under an atmospheric pressure of CO gas. Various functional groups such as carbonyl, cyano, halo, and sulfonyl groups were well tolerated under the present catalysis. Since aryldimethylsulfoniums were readily prepared from the corresponding aryl methyl sulfides and methyl triflate, one-pot alkoxycarbonylation of aryl methyl sulfides could be accomplished.

Metal-free radical aromatic carbonylations mediated by weak bases

We report a new method of metal-free alkoxycarbonylation. This reaction involves the generation of aryl radicals from arenediazonium salts by a very weak base (HCO2Na) under mild conditions. Subsequent radical trapping with carbon monoxide and alcohols gives alkyl benzoates. The conditions (metal-free, 1 equiv. base, MeCN, r.t., 3 h) tolerate various functional groups (I, Br, Cl, CF3, SF5, NO2, ester). Mechanistic studies indicate the operation of a radical aromatic substitution mechanism.

Cobalt-Catalyzed Esterification of Amides

The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.

Synthetic method of an ester compound

The invention discloses a synthetic method of an ester compound and belongs to the technical field of organic synthesis. The synthetic method includes the steps of: dissolving an aldehyde compound (1) and a halogenated hydrocarbon compound (2) in a solvent, adding an oxidant and a catalyst, and performing a reaction at 60-100 DEG C to obtain the target product ester compound (3). A reaction equation of the synthetic method is represented as follows. The method, compared with the prior art, has the following advantages: 1) the raw materials are easy to obtain and are low in cost; 2) the reaction conditions are mild, operations are simple, and reaction time is short; and 3) a substrate has wide available range and can be used for synthesis of various ester compounds.