54231-36-6

Usage

Uses

Used in Pharmaceutical Industry:
3-CHLORO-2-(4-MORPHOLINO)PYRIDINE is used as a key intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs. Its diverse biological activities and structural features contribute to the creation of innovative therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical sector, 3-CHLORO-2-(4-MORPHOLINO)PYRIDINE serves as an essential intermediate in the production of agrochemicals, aiding in the development of effective and targeted pest control solutions.
Used in Specialty Chemicals:
3-CHLORO-2-(4-MORPHOLINO)PYRIDINE is utilized as a building block in the synthesis of specialty chemicals, where its unique properties can be leveraged to create high-value products for specific applications.
Used in Research and Development:
3-CHLORO-2-(4-MORPHOLINO)PYRIDINE is also widely used in research and development processes across various scientific fields, enabling the exploration of new chemical reactions and the discovery of novel compounds with potential applications.

Upstream product

• 110-91-8 morpholine 
• 54231-32-2 3-chloro-2-nitropyridine 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 77332-89-9 2-iodo-3-pyridyl chloride 
• 96424-68-9 2-bromo-3-chloropyridine 

Relevant academic research and scientific papers

Streamlined Synthesis of Diaminopyridines by Pd-Catalyzed Ammonia Coupling with Deactivated Amino-Chloropyridines

An efficient and cost-effective two-step synthesis of diaminopyridines, fundamental building blocks of biologically active compounds, is reported. The advantages over previously reported routes include cost and wider availability of the bromo-chloropyridine starting materials and the straightforward accessibility to an extended array of diaminopyridine regioisomers. The key enabler of this synthetic strategy is the development of an unprecedented palladium-catalyzed coupling reaction of ammonia with chloropyridines deactivated by the presence of an alkylamino substituent. The coupling reaction was accomplished with very low catalyst loadings under remarkably mild reaction conditions, making the system particularly suitable for both academic and industrial applications. The utility of this methodology is exemplified by the application to the synthesis of highly relevant scaffolds, including the synthetic intermediates of the marketed drugs Ribociclib and Palbociclib.

Cobalt-Catalyzed Electrophilic Amination of Aryl- and Heteroarylzinc Pivalates with N-Hydroxylamine Benzoates

Aryl- and heteroarylzinc pivalates can be aminated with O-benzoylhydroxylamines at 25 °C within 2–4 h in the presence of 2.5–5.0 % CoCl2?2 LiCl to furnish the corresponding tertiary arylated or heteroarylated amines in good yields. This electrophilic amination also provides access to diarylamines and aryl(heteroaryl)amines. A new tuberculosis drug candidate (Q203) was prepared in six steps and 56 % overall yield by using this cobalt-catalyzed amination as the key step.