54232-43-8

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H6BrNO3/c1-12-5-3-2-4(7(10)11)9-6(5)8/h2-3H,1H3,(H,10,11)

Upstream product

• 24207-22-5 2-bromo-3-methoxy-6-methyl-pyridine 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 23003-35-2 2-bromo-3-hydroxy-6-methylpyridine 
• 29082-92-6 5-methoxypyridine-2-carboxylic acid 
• 672957-93-6 5-methoxypicolinic acid N-oxide 

Downstream Products

• 170235-18-4 methyl 2-bromo-3-methoxy-6-pyridinecarboxylic acid 
• 1610625-66-5 N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-carbonyl(2-mercaptothiazolide)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine 
• 1610625-65-4 N,N''-bis[1-benzyloxy-2-oxo-3-[(carboxyamidomethyl)oxy]-6-(methoxycarbonyl)pyridine]-N'-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-bis(2-aminoethyl)amine 
• 1610625-64-3 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid 6-methyl ester 
• 1610625-63-2 1-benzyloxy-2-oxo-3-[(carboxymethyl)oxy]-6-pyridinecarboxylic acid dimethyl ester 
• 1415898-97-3 6-(3-Chlorophenyl)-5-methoxy-pyridine-2-carboxylic acid 
• 1391846-44-8 (S)-3-[(6-bromo-5-methoxy-pyridine-2-carbonyl)-amino]-3-(2-chloro-phenyl)-propionic acid ethyl ester 
• 178876-92-1 6-Bromo-5-hydroxy-pyridine-2-carboxylic acid 
• 170235-19-5 methyl 2-bromo-3-hydroxy-6-pyridinecarboxylate 

Relevant academic research and scientific papers

HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The invention relates to a novel heterocyclic compound inhibiting a cyclin-dependent kinase (CDK) and a pharmaceutical composition comprising the same as an effective ingredient. The heterocyclic compound according to the present invention or pharmaceutically acceptable salt thereof can be effectively used in treating or preventing cancers, degenerative brain diseases, etc.

COMPOSITIONS AND USES OF AMIDINE DERIVATIVES

Use of a compound of formula (I): wherein A, X, Y, R1 and R2 as defined herein, in treating hereditary angioedema is disclosed. A composition containing the compounds, a polar organic solvent or a mixture thereof; and optionally a co-solvent, is also disclosed.

DI-MACROCYCLES

The invention relates to chemical compounds and complexes that can be used in therapeutic and diagnostic applications.

NOVEL PYRIDINE DERIVATIVES

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

PYRIDIN- 2 -AMIDES USEFUL AS CB2 AGONISTS

The invention relates to a compound of formula (I) wherein R1 to R4 are defined as in the description and in the claims. The compound of formula (I) can be used as a medicament.

Total synthesis of dimethyl sulfomycinamate

Dimethyl sulfomycinamate (1), a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chemistry of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined. The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on doubly activated pyridine 62 and the condensation reaction between bromo ketone 69 and amide 28 to form the oxazole moiety 76. The first preparation of oxazole triflates is described, as are some of their chemical properties.

Total synthesis of dimethyl sulfomycinamate

The first total synthesis of dimethyl sulfomycinamate (1) is described. Highlights of the synthesis include a selective palladium-catalyzed coupling reaction on the bromotriflate 21, and a condensation reaction to form the oxazole ring.