54239-59-7

Basic information

• Product Name: 2-amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile
• CAS NO: 54239-59-7
• Molecular Formula: C₁₃H₁₈ClN₃O
• Molecular Weight: 267.7545
• Mol File: 54239-59-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 431°C at 760 mmHg
• Flash Point: 214.4°C
• Density: 1.22g/cm³
• Vapor Pressure: 3.41E-08mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: 2-amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile(54239-59-7)
• EPA Substance Registry System: 2-amino-5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chlorobenzonitrile(54239-59-7)

Safety Data

• Hazardous Substances Data: 54239-59-7(Hazardous Substances Data)

Upstream product

• 88167-51-5 2-amino-5-(2-bromoacetyl)-3-chlorobenzonitrile 
• 97760-78-6 4'-amino-3'-chloro-5'-cyano-acetophenone 
• 97776-06-2 4-acetyl-2-iodoaniline 
• 99-92-3 p-aminobenzophenone 
• 33720-71-7 4-amino-3-cyanoacetophenone 
• 54239-60-0 4'-amino-3'-chloro-5'-cyano-2-tert.butylamino-acetophenone 

Downstream Products

• 82171-35-5 5-[2-(tert-butylamino)-1-hydroxyethyl]-3-chloroanthranilic acid, methyl ester, hydrochloride 

Relevant articles and documents

Synthesis of further amino-halogen-substituted phenyl-aminoethanols

Starting from clenbuterol as a lead structure, new 4-amino-phenyl-aminoethanol analogues have been synthesized by different approaches. In these compounds one or both of the chlorine atoms of clenbuterol are replaced by other residues. This has led to compounds with high intrinsic β2-mimetic and/or β1-blocking activities. 1-(4-Amino-3-chloro-5-trifluoromethyl-phenyl)-2-tert.-butylamino-ethanol hydrochloride (mabuterol) has been selected for clinical development. A detailed description is also given of the syntheses of new intermediate acetophenone derivatives as well as of the resolution of mabuterol into its enantiomers.

Phenylethanolamine derivatives and acid addition salts thereof for the depression of fat deposition in warm blooded animals

There is provided a method for increasing lean meat deposition and/or improving lean meat to fat ratio in poultry, domestic pets, sheep, swine, rabbits, goats and cattle by administering, orally or parenterally, to said animals an effective amount of a phenylethane derivative or acid salt thereof.

BRONCHOSPASMOLYTIC 1-(P-AMINO-PHENYL)-2-AMINO-ETHANOLS-(1) AND SALTS

Racemic and optically active compounds of the formula wherein R1 is hydrogen, fluorine, chlorine, bromine, iodine or cyano, R2 is fluorine, trifluoromethyl, nitro or cyano, and R3 is alkyl of 3 to 5 carbon atoms, hydroxy(alkyl of 3 to 5 carbon atoms), cycloalkyl of 3 to 5 carbon atoms, 1-(3,4-methylenedioxy-phenyl)-2-propyl or 1-(p-hydroxy-phenyl)-2-propyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as analgesics, uterospasmolytics, bronchospasmolytics and antispastics for the skeletal musculature, and especially as beta 2-receptor mimetics and beta 1-receptor blockers