97776-06-2

Basic information

• Product Name: 1-(4-aMino-3-iodophenyl)ethanone
• Synonyms: 1-(4-aMino-3-iodophenyl)ethanone
• CAS NO: 97776-06-2
• Molecular Formula: C₈H₈INO
• Molecular Weight: 261.05969
• Mol File: 97776-06-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-aMino-3-iodophenyl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-aMino-3-iodophenyl)ethanone(97776-06-2)
• EPA Substance Registry System: 1-(4-aMino-3-iodophenyl)ethanone(97776-06-2)

Safety Data

• Hazardous Substances Data: 97776-06-2(Hazardous Substances Data)

Usage

Appearance

Yellow solid

Usage

Building block in the synthesis of various pharmaceuticals and other organic compounds

Structural features

Amino group (NH2) attached to a phenyl ring
Iodine atom (I) attached to a phenyl ring
Ketone group (C=O) attached to an ethyl group (CH3CH2)

Potential reactivity

Can participate in a variety of chemical reactions due to the presence of the amino, iodine, and ketone groups

Applications

Development of new drugs
Development of new materials
Fields of medicinal chemistry and organic synthesis

Upstream product

• 99-92-3 p-aminobenzophenone 

Downstream Products

• 33720-71-7 4-amino-3-cyanoacetophenone 
• 936840-08-3 1-(4-amino-3-ethynylphenyl)ethanone 
• 53330-94-2 1-(1H-indol-5-yl)ethanone 
• 919124-08-6 4-bromo-3-iodoacetophenone 
• 1030373-71-7 N-(4-acetyl-2-iodophenyl)acetamide 
• 1030373-97-7 3-iodo-4-(acrylamido)acetophenone 
• 31380-57-1 5-acetyl-1H-indole-2-carboxylic acid 
• 1253972-45-0 ethyl 3-(5-acetyl-2-aminophenyl)acrylate 
• 1356126-62-9 methyl 6-acetylquinoline-2-carboxylate 
• 19989-44-7 1-(2-phenylbenzothiazol-6-yl)ethanone 
• 1403488-71-0 1-(4-amino-3-(3-hydroxy-3-methylbut-1-yn-1-yl)phenyl)ethanone 
• 1416246-63-3 1-(2-(4-(4-methoxyphenyl)piperazine-1-carbonyl)-1H-indol-5-yl)ethanone 
• 1433218-52-0 C₁₇H₁₇NO₃S₂ 
• 1433218-70-2 N-(4-acetyl-2-iodophenyl)-N-(2-bromoethyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Cu(II)-Promoted Cascade Synthesis of Fused Imidazo-Pyridine-Carbonitriles

A Cu(II)-promoted synthesis of an aza-fused N-heterocycle having a benz-imidazopyridine scaffold is developed via an addition-cyclization reaction followed by an Ullmann-type C-N coupling between o-iodoanilines and γ-ketodinitriles. This protocol features a broad substrate scope, giving products in 32-84% yields. The compounds show excellent photoluminescence properties having two absorption maxima in the region between 270-280 and 338-350 nm and emission maxima in the range of 502-533 nm. The HOMO-LUMO energy gap of 3.49-3.57 eV was determined using Gaussian 09 at the B3LYP/6-31G (d, p) basis set level. We also demonstrated a few postsynthetic modifications.

SULFONYL-SUBSTITUTED BICYCLIC COMPOUND WHICH ACTS AS ROR INHIBITOR

Provided is a sulfonyl-substituted bicyclic compound (A) which acts as a RORγ inhibitor, said compound has good RORγ inhibitory activity and is expected to be used for treating diseases mediated by a RORγ receptor in mammals.

Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization

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Silver(I)-catalyzed iodination of arenes: Tuning the lewis acidity of N-iodosuccinimide activation

A mild and rapid method for the iodination of arenes that utilizes silver(I) triflimide as a catalyst for activation of N-iodosuccinimide has been developed. The transformation was found to be general for a wide range of anisole, aniline, acetanilide, and phenol derivatives and allowed the late-stage iodination of biologically active compounds such as PIMBA, a SPECT imaging agent of breast cancer, and (a?)-IBZM, a dopamine D2 receptor antagonist. The method was also modified for the radioiodination of arenes using a one-pot procedure involving the in situ generation of [125I]-N-iodosuccinimide followed by the silver(I)-catalyzed iodination.

Double (amino-sulfur generation of formic acid ) - 1,3-propane diester compound and its synthetic method, pharmaceutical composition and use thereof

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Diversely Substituted Quinolines via Rhodium-Catalyzed Alkyne Hydroacylation

The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onward to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group

A dramatic enhancing effect of InBr3 towards the oxidative Sonogashira cross-coupling reaction of 2-ethynylanilines

The addition of InBr3 to the oxidative Sonogashira cross-coupling reaction of 2-ethynylaniline with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane led to a dramatic increase in the reactivity to afford the corresponding 1,3-enynes bearing a trifluoromethyl group on their terminal sp2 carbon. The subsequent cyclization of these 1,3-enynes under palladium catalysis provides access to the corresponding indoles bearing a 3,3,3-trifluoroprop-1-enyl group at their 2-position.

Highly Regioselective Iodination of Arenes via Iron(III)-Catalyzed Activation of N-Iodosuccinimide

An iron(III)-catalyzed method for the rapid and highly regioselective iodination of arenes has been developed. Use of the powerful Lewis acid, iron(III) triflimide, generated in situ from iron(III) chloride and a readily available triflimide-based ionic liquid allowed activation of N-iodosuccinimide (NIS) and efficient iodination under mild conditions of a wide range of substrates including biologically active compounds and molecular imaging agents.

Consecutive gold(I)-catalyzed cyclization reactions of o -(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas: A one-pot synthesis of pyrimido[1,6- a ]indol-1(2 H)-ones and related systems

Treatment of readily available o-(buta-1,3-diyn-1-yl-)-substituted N-aryl ureas such as 1 with the Au(I)-catalyst 11 affords, via a twofold cyclization process, the isomeric pyrimido[1,6-a]indol-1(2H)-one 3 in good yield.

NEW COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neurological disorders, such as disorders collectively known as tauopathies, and disorders characterised by cytotoxic α-synuclein amyloidogenesis. The present invention also relates to the use of said novel compounds for the manufacture of medicaments useful for treating such neurodegenerative disorders. The present invention further relates to pharmaceutical compositions including said novel compounds and to methods for the preparation of said novel compounds. The compounds have the formula (A1) wherein R1, R2, R4, R6, E, n, Y1, Y2, Y3, Y4, Y5, L, B, R8, and m are as defined in the claims.