5424-50-0

Usage

Uses

Used in Pharmaceutical Industry:
Benzenemethanol, a-[2-(dimethylamino)ethyl]-,hydrochloride (1:1) is used as an active ingredient in the production of medications that act on the central nervous system, such as antidepressants and antipsychotics. Its psychoactive properties make it a valuable component in the development of these types of drugs.
It should be noted that the handling and use of Benzenemethanol, a-[2-(dimethylamino)ethyl]-,hydrochloride (1:1) should be done with care and only under the supervision of qualified professionals to ensure safety and effectiveness.

Upstream product

• 3506-36-3 3-dimethylaminopropiophenone 
• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 

Downstream Products

• 72084-03-8 N,N-dimethyl-γ-(3-nitrophenoxy)-benzene-propanamine 
• 72084-00-5 N,N-dimethyl-3-(4-nitrophenoxy)-3-phenylpropan-1-amine 
• 1011-59-2 3-(dimethylamino)-1-phenylpropyl chloride hydrochloride 

Relevant academic research and scientific papers

AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.

Use of achiral (diphosphine)RuCl2(diamine) precatalysts as a practical alternative to sodium borohydride for ketone reduction

Stoichiometric sodium borohydride is frequently used in the chemoselective reduction of ketones to racemic secondary alcohols. Catalytic homogeneous hydrogenation using (diphosphine)RuCl2(diamine) complexes provides a practical and economic alternative. A range of substrates were investigated and the optimum precatalyst identified in each case. Norcamphor was reduced with high diastereoselectivity using (Ph3P)2-RuCl 2(en); (E)-4-phenylbut-3-en-2-one was reduced with good chemoselectivity, and acetophenone was hydrogenated very efficiently using the same precatalyst. Isophorone and 3-dimethylaminopropiophenone were effectively hydrogenated using (dppf)RuCl2(en).