72084-00-5

Upstream product

• 5424-50-0 NSC 12229 
• 100-00-5 4-chlorobenzonitrile 
• 3506-36-3 3-dimethylaminopropiophenone 
• 100-02-7 4-nitro-phenol 
• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 

Downstream Products

• 72084-11-8 4-(3-(dimethylamino)-1-phenylpropoxy)aniline 
• 1584112-39-9 N-(4-(3-(dimethylamino-1-phenylpropoxy)phenyl)-5-methoxy-6-trifluoromethyl)indoline-1-carboxamide 
• 1608117-98-1 C₂₇H₃₀N₄O₂ 
• 1608117-99-2 C₂₇H₃₀N₄O₂ 
• 1608118-00-8 C₂₈H₂₉N₃O₂ 
• 1608118-03-1 C₂₈H₃₂N₄O₂ 
• 1608118-04-2 C₂₅H₂₇N₅O₂ 
• 1608118-05-3 C₂₄H₂₅Cl₂N₃O₂ 
• 1608118-06-4 C₂₅H₂₈ClN₃O₂ 
• 1608118-07-5 C₂₅H₂₈IN₃O₂ 
• 1608118-08-6 C₂₅H₂₈ClN₃O₃ 
• 1608118-09-7 C₂₆H₂₈F₃N₃O₃ 
• 1608118-10-0 C₂₆H₂₈F₃N₃O₂S 
• 1608118-11-1 C₂₅H₂₈ClN₃O₃ 

Relevant academic research and scientific papers

Design of novel multiple-acting ligands towards SERT and 5-HT2C receptors

This Letter describes our attempts to elaborate dually acting compounds possessing serotonin re-uptake transporter inhibitor and serotonin 5-HT 2C receptor antagonist properties. A novel series of 1,3-diphenylureas and N-phenylbenzamides have thus been prepared and evaluated. Based on its in vitro and in vivo activities, as well as pharmacokinetic profile, compound 16a was identified as a lead compound. The synthesis and structure-activity relationship of this series of compounds is presented herein.

SUBSTITUTED 3-HETEROARYLOXY-3-(HETERO)ARYL-PROPYLAMINES AS SEROTONIN TRANSPORTER AND SEROTONIN HT2C RECEPTOR MODULATORS

The present invention relates to compounds compound according to Formula (1): and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have serotonin (5-HT) transporter inhibitory effects and 5-HT 2C receptor antagonist or inverse agonist effects. The present invention also relates to pharmaceutical compositions comprising these compounds, and methods of using them for application in the prophylaxis or treatment of CNS disorders.