1011-59-2

Usage

Uses

Used in Pharmaceutical Industry:
N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE is used as a key intermediate in the production of various pharmaceuticals. Its chemical properties make it suitable for the synthesis of a range of organic compounds, contributing to the development of new medications.
Used in Agrochemical Industry:
In the agrochemical sector, N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE serves as an essential component in the synthesis of agrochemicals, aiding in the creation of products that enhance crop protection and yield.
Used in Organic Synthesis:
N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE is utilized as a reagent in various chemical reactions, facilitating the synthesis of different organic compounds for a multitude of applications across various industries.
Used in Psychiatric Research:
N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE has been studied for its potential therapeutic effects in the treatment of depression and other psychiatric disorders, indicating its importance in the field of mental health research.
It is crucial to handle N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE with caution due to its potential hazards if not properly managed, emphasizing the need for safe practices in its application and use.

Upstream product

• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 
• 5424-50-0 NSC 12229 
• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 98-86-2 acetophenone 

Downstream Products

• 81402-45-1 Dimethyl-(3-phenyl-3-piperidin-1-yl-propyl)-amine 
• 81402-37-1 3-[4-(3-Dimethylamino-1-phenyl-propyl)-piperazin-1-yl]-propan-1-ol 
• 81402-43-9 1-(3-dimethylamino-1-phenylpropyl)-4-(ethoxycarbonyl)piperazine 
• 79332-96-0 N,N-Dimethyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine 
• 134673-81-7 N,N-dimethyl-3-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)-3-phenylpropylamine 
• 107688-86-8 N,N-dimethyl-3-(o-tolyloxy)-3-phenyl-propylamine oxalate 
• 126407-27-0 N,N-dimethyl-γ-[4-(methylthio)phenoxy]benzenepropanamine ethanedioate 
• 56225-81-1 N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine 
• 83015-25-2 N,N-dimethyl-3-(2-methyl-phenyloxy)-3-phenyl-propanamine 
• 1219503-99-7 N₁-[2-(7-chloroquinolin-4-ylamino)ethyl]-N₃,N₃-dimethyl-1-phenylpropane-1,3-diamine 
• 92208-24-7 N-Methyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine 
• 81402-50-8 1-(3-dimethylamino-1-phenylpropyl)-4-(cyclopropylmethyl)piperazine 
• 81402-49-5 1-(3-dimethylamino-1-phenylpropyl)piperazine 
• 79332-98-2 ethyl N-methyl-N-<3-(2-benzyloxyphenoxy)-3-phenylpropyl>carbamate 

Relevant academic research and scientific papers

Fluoxetine scaffold to design tandem molecular antioxidants and green catalysts

Fluoxetine finds application in the treatment of depression and mood disorders. This selective serotonin-reuptake inhibitor (SSRI) also contrasts oxidative stress by direct ROS scavenging, modulation of the endogenous antioxidant defense system, and/or enhancement of the serotonin antioxidant capacity. We synthesised some fluoxetine analogues incorporating a selenium nucleus, thus expanding its antioxidant potential by enabling a hydroperoxides-inactivating, glutathione peroxidase (GPx)-like activity. Radical scavenging and peroxidatic activity were combined in a water-soluble, drug-like, tandem antioxidant molecule. Selenofluoxetine derivatives were reacted with H2O2in water, and the mechanistic details of the reaction were unravelled combining nuclear magnetic resonance (NMR), electrospray ionisation-mass spectrometry (ESI-MS) and quantum chemistry calculations. The observed oxidation-elimination process led to the formation of seleninic acid and cinnamylamine in atrans-selective manner. This mechanism is likely to be extended to other substrates for the preparation of unsaturated cinnamylamines.

Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and mannich bases: Interaction with DNA

The synthesis and biological evaluation of new organic and organometallic dual drugs designed as potential antimalarial agents are reported. A series of 4-aminoquinoline-based Mannich bases with variations in the aliphatic amino side chain were prepared via a three-steps synthesis. These compounds were also tested against chloroquine-susceptible and chloroquine-resistant strains of Plasmodium falciparum and assayed for their ability to inhibit the formation of β-hematin in vitro using a colorimetric β-hematin inhibition assay. Several compounds showed a marked antimalarial activity, with IC50 and IC90 values in the low nM range but also a high cytotoxicity against mammalian cells, in particular a highly drug-resistant glioblastoma cell line. The newly designed compounds revealed high DNA binding properties, especially for the GC-rich domains. Altogether, these dual drugs seem to be more appropriate to be developed as antiproliferative agents against mammalian cancer cells than Plasmodium parasites.

AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.

Aryloxyphenylpropylamines and their preparation and use

Novel aryloxyphenylpropylamines having the formula STR1 wherein R1 is C3-7 -cycloalkyl, C3-10 -alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4 -alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl; and R2 is 3,4-methylenedioxyphenyl, aryl or heteroaryl, which are optionally substituted with one or more cyano, halogen, C1-6 -alkyl, C1-6 -alkoxy, C1-6 -alkenyl, trifluoromethyl, C3-5 -alkylene, aryloxy or aralkoxy and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.

Treatment of obesity with aryloxyphenylpropylamines

3-Aryloxy-3-phenylpropylamines and acid addition salts thereof are useful in blocking uptake of monoamines by brain neurons, and are thus effective in treating disorders of sleep, sexual performance, appetite, muscular function, and pituitary function.

Aryloxyphenylpropylamines in treating depression

3-Aryloxy-3-phenylpropylamines and acid additions salts thereof, useful as psychotropic agents, particularly as anti-depressants.