1011-59-2

Basic information

• Product Name: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE
• Synonyms: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE;3-chloro-N,N-dimethyl-3-phenylpropan-1-amine:hydrochloride;Benzenepropanamine, γ-chloro-N,N-dimethyl-, hydrochloride (1:1)
• CAS NO: 1011-59-2
• Molecular Formula: C₁₁H₁₆ClN*ClH
• Molecular Weight: 234.168
• Mol File: 1011-59-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE(1011-59-2)
• EPA Substance Registry System: N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE(1011-59-2)

Safety Data

• Hazardous Substances Data: 1011-59-2(Hazardous Substances Data)

Usage

General Description

N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE is a chemical compound that belongs to the class of alkylamines. It is a white crystalline solid that is soluble in water and other organic solvents. N,N-DIMETHYL-3-PHENYL-3-CHLOROPROPYLAMINE HYDROCHLORIDE is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. It is also used in the synthesis of various organic compounds and as a reagent in chemical reactions. Additionally, it has been studied for its potential applications in the treatment of depression and other psychiatric disorders. However, it is important to handle this chemical with care as it can be hazardous if not properly managed and used.

Upstream product

• 879-72-1 3-(dimethylamino)propiophenone hydrochloride 
• 98-86-2 acetophenone 
• 5424-50-0 NSC 12229 
• 5554-64-3 N,N-dimethyl-3-hydroxy-3-phenylpropylamine 

Downstream Products

• 81402-45-1 Dimethyl-(3-phenyl-3-piperidin-1-yl-propyl)-amine 
• 134673-81-7 N,N-dimethyl-3-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)-3-phenylpropylamine 
• 83015-25-2 N,N-dimethyl-3-(2-methyl-phenyloxy)-3-phenyl-propanamine 
• 1219503-99-7 N₁-[2-(7-chloroquinolin-4-ylamino)ethyl]-N₃,N₃-dimethyl-1-phenylpropane-1,3-diamine 
• 56225-81-1 N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine 
• 126407-27-0 N,N-dimethyl-γ-[4-(methylthio)phenoxy]benzenepropanamine ethanedioate 
• 92208-24-7 N-Methyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine 
• 81402-50-8 1-(3-dimethylamino-1-phenylpropyl)-4-(cyclopropylmethyl)piperazine 
• 81402-49-5 1-(3-dimethylamino-1-phenylpropyl)piperazine 
• 79332-98-2 ethyl N-methyl-N-<3-(2-benzyloxyphenoxy)-3-phenylpropyl>carbamate 
• 107688-86-8 N,N-dimethyl-3-(o-tolyloxy)-3-phenyl-propylamine oxalate 
• 79332-96-0 N,N-Dimethyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine 
• 81402-41-7 [3-(4-Benzyl-piperazin-1-yl)-3-phenyl-propyl]-dimethyl-amine 
• 81402-43-9 1-(3-dimethylamino-1-phenylpropyl)-4-(ethoxycarbonyl)piperazine 

Relevant articles and documents

Fluoxetine scaffold to design tandem molecular antioxidants and green catalysts

Fluoxetine finds application in the treatment of depression and mood disorders. This selective serotonin-reuptake inhibitor (SSRI) also contrasts oxidative stress by direct ROS scavenging, modulation of the endogenous antioxidant defense system, and/or enhancement of the serotonin antioxidant capacity. We synthesised some fluoxetine analogues incorporating a selenium nucleus, thus expanding its antioxidant potential by enabling a hydroperoxides-inactivating, glutathione peroxidase (GPx)-like activity. Radical scavenging and peroxidatic activity were combined in a water-soluble, drug-like, tandem antioxidant molecule. Selenofluoxetine derivatives were reacted with H2O2in water, and the mechanistic details of the reaction were unravelled combining nuclear magnetic resonance (NMR), electrospray ionisation-mass spectrometry (ESI-MS) and quantum chemistry calculations. The observed oxidation-elimination process led to the formation of seleninic acid and cinnamylamine in atrans-selective manner. This mechanism is likely to be extended to other substrates for the preparation of unsaturated cinnamylamines.

AN IMPROVED PROCESS FOR SYNTHESIZING HIGHLY PURE ATOMOXETINE

The present invention relates to a process for the preparation of highly pure atomoxetine of formula (I) and pharmaceutically acceptable salts thereof Formula (I) The present invention also aims at novel processes for the preparation and purification of intermediates involved in the process of the present invention.

Aryloxyphenylpropylamines and their preparation and use

Novel aryloxyphenylpropylamines having the formula STR1 wherein R1 is C3-7 -cycloalkyl, C3-10 -alkyl, or alkenyl which may be straight, branched or cyclic, unsubstituted or substituted with C1-4 -alkoxy, aryloxy or cycloalkyl or cycloalkylalkyl; and R2 is 3,4-methylenedioxyphenyl, aryl or heteroaryl, which are optionally substituted with one or more cyano, halogen, C1-6 -alkyl, C1-6 -alkoxy, C1-6 -alkenyl, trifluoromethyl, C3-5 -alkylene, aryloxy or aralkoxy and a salt thereof with a pharmaceutically acceptable acid. The novel compounds are useful in the treatment of anoxia, migraine, ischemia and epilepsy.