54241-17-7Relevant academic research and scientific papers
Synthesis of nitrogen heterocycles via α-aminoalkyl radicals generated from α-silyl secondary amines under visible light irradiation
Nakajima, Kazunari,Kitagawa, Mai,Ashida, Yuya,Miyake, Yoshihiro,Nishibayashi, Yoshiaki
supporting information, p. 8900 - 8903 (2014/08/05)
We have succeeded in the visible light-mediated synthetic use of α-aminoalkyl radicals derived from α-silyl secondary amines toward addition to α,β-unsaturated carbonyl compounds. The resulting γ-aminocarbonyl compounds are converted into γ-lactams and pyrroles in a one-pot process. This journal is the Partner Organisations 2014.
Integration of heterogeneous catalysts into complex synthetic routes: Sequential vs. one-pot reactions in a (Knoevenagel + Mukaiyama-Michael + hydrogenation + transesterification) sequence
Fraile, Jose M.,Garcia, Nuria,Herrerias, Clara I.,Mayoral, Jose A.
, p. 436 - 443 (2013/03/28)
Heterogeneous catalysts of different nature can be combined in one-pot tandem reactions, but the compatibility issues of catalysts with reagents, products, and by-products make more convenient the application of a sequential procedure, in which the catalyst is filtered after each reaction and the crude is used in the following reaction without purification. In this way the recovery and reuse of each catalyst can be optimized to obtain the maximum productivity. The nature of the reactions, and the catalysts involved in them, conditions the maximum number of successive steps in the sequence. In the case of the (Knoevenagel + Mukaiyama-Michael + hydrogenation + transesterification) process tested in this work, the optimal results are obtained when the sequential method is applied to only three reactions, whereas the four reactions sequence shows limitations in the yield of the last transesterification step. The Royal Society of Chemistry 2013.
Nickel(ii)-catalyzed enantioselective 1,3-dipolar cycloaddition of azomethine imines with alkylidene malonates
Li, Jiangting,Lian, Xiangjin,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
supporting information, p. 5134 - 5140 (2013/07/05)
We demonstrated an asymmetric 1,3-dipolar cycloaddition of azomethine betaines with alkylidene malonates by using a chiral N,N'-dioxide- NiII complex as a catalyst. Both aromatic- and aliphatic-substituted alkylidene malonates were found to be suitable for the reaction. A range of transpyrazolone derivatives was exclusively obtained with excellent yields (up to 99% yield) and good enantioselectivities (up to 97% ee) under mild reaction conditions. The reaction could be carried out on a gram scale with the good results being maintained. Control experiments were performed to elucidate the specific diastereoselectivity of the reaction. The formation of single trans isomers was dominated by secondary orbital interactions between the ester groups of the dipolarophile and the azomethine imine. On the basis of the experimental results and previous reports, a possible catalytic model was assumed.
Asymmetric cyanation of activated olefins with ethyl cyanoformate catalyzed by a modular titanium catalyst
Wang, Jun,Li, Wei,Liu, Yanling,Chu, Yangyang,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming
supporting information; experimental part, p. 1280 - 1283 (2010/06/15)
"Chemical Equation Presented" Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5,6, and pharmaceutically Important γ-aminobutyric acid 7.
A labeled neutral endopeptidase inhibitor as a potential tool for tumor diagnosis and prognosis
Raguin, Olivier,Fournie-Zaluski, Marie-Claude,Romieu, Anthony,Pelegrin, Andre,Chatelet, Francois,Pelaprat, Didier,Barbet, Jacques,Roques, Bernard P.,Gruaz-Guyon, Anne
, p. 4058 - 4061 (2007/10/03)
(Chemical Equation Presented) Specific targeting of tumors with radioactive isotopes is the key for high-sensitivity scintigraphy detection. A labeled neutral endopeptidase (NEP) inhibitor is described that accumulates in vivo in tumor cells expressing th
