Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester

Base Information

• Chemical Name: Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester
• CAS No.: 54241-17-7
• Molecular Formula: C20H20O4
• Molecular Weight: 324.37
• Hs Code.: 2917399090
• Mol file: 54241-17-7.mol

Synonyms:Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester

Chemical Property of Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester

Chemical Property:

• PSA: 12.89000
• LogP: 2.11470

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester

There total 1 articles about Propanedioic acid,[(1,1'-biphenyl)-4-yl-methylene]-,diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-Phenylbenzaldehyde (3218-36-8) + diethyl malonate (105-53-3) → 2-biphenyl-4-ylmethylene-malonic acid diethyl ester (54241-17-7)

Guidance literature:

With C₁₆H₁₄MnN₂O₂⁽¹⁺⁾*[(Si₃Mg_5.5Li_0.3)O₂₀(OH)4]^(1-); In toluene; at 120 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2cy20442h

Reference yield: 96.0%

1-benzylidene-3-oxo-1-pyrazolidinium-2-ide (17822-51-4) + 2-biphenyl-4-ylmethylene-malonic acid diethyl ester (54241-17-7) → (1R,3R)-diethyl 3-(biphenyl-4-yl)-5-oxo-1-phenyltetrahydropyrazolo[1,2-a]pyrazole-2,2(1H)-dicarboxylate

Guidance literature:

With C₂₃H₄₄N₄O₄; nickel(II) perchlorate hexahydrate; In dichloromethane; at 30 ℃; for 20h; enantioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1002/chem.201203891

Reference yield: 83.0%

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one (141293-14-3) + 2-biphenyl-4-ylmethylene-malonic acid diethyl ester (54241-17-7) → tert-butyl 2-(3-ethoxy-2-(ethoxycarbonyl)-3-oxo-1-phenylpropyl)-5-oxo-2H-pyrrole-1(5H)-carboxylate (1374878-16-6)

Guidance literature:

N-(tert-butoxycarbonyl)pyrrol-2(5H)-one; With C₄₃H₆₀N₆O₂; In α,α,α-trifluorotoluene; at 20 ℃; Molecular sieve;

2-biphenyl-4-ylmethylene-malonic acid diethyl ester; In α,α,α-trifluorotoluene; at 30 ℃; for 18h; optical yield given as %ee; Molecular sieve;

DOI:10.1039/c2cc31470c

upstream raw materials:

4-Phenylbenzaldehyde

diethyl malonate

Downstream raw materials:

2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid

2-biphenyl-4-ylmethyl-acrylic acid benzyl ester

2-(2-biphenyl-4-ylmethyl-3-{hydroxy-[1-(1-isobutyryloxy-ethoxycarbonylamino)ethyl]phosphinoyl}propionylamino)propionic acid benzyl ester

C₃₃H₃₄NO₆P

Refernces

• 1、 Fraile, Jose M.,Garcia, Nuria,Herrerias, Clara I.,Mayoral, Jose A.. "Integration of heterogeneous catalysts into complex synthetic routes: Sequential vs. one-pot reactions in a (Knoevenagel + Mukaiyama-Michael + hydrogenation + transesterification) sequence". . p. 436 - 443. Retrieved 2013/03/28.
• 2、 Wang, Jun,Li, Wei,Liu, Yanling,Chu, Yangyang,Lin, Lili,Liu, Xiaohua,Feng, Xiaoming. "Asymmetric cyanation of activated olefins with ethyl cyanoformate catalyzed by a modular titanium catalyst". supporting information; experimental part. p. 1280 - 1283. Retrieved 2010/06/15.