54253-05-3

Basic information

• Product Name: 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide
• Synonyms: 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide
• CAS NO: 54253-05-3
• Molecular Formula: C₁₃H₈Cl₂N₂O₃
• Molecular Weight: 311.12022
• Mol File: 54253-05-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide(54253-05-3)
• EPA Substance Registry System: 2-chloro-N-(4-chlorophenyl)-5-nitrobenzamide(54253-05-3)

Safety Data

• Hazardous Substances Data: 54253-05-3(Hazardous Substances Data)

Upstream product

• 2516-96-3 2-chloro-5-nitrobenzoic acid 
• 106-47-8 4-chloro-aniline 
• 25784-91-2 2-chloro-5-nitrobenzoylchloride 

Downstream Products

• 1421846-70-9 11-(4-chlorophenyl)-8-nitro-3-(trifluoromethyl)benzo[f]pyrido[3,2-b][1,4]thiazepin-10(11H)one 
• 1421846-58-3 6-chloro-10-(4-chlorophenyl)-2-nitrodibenzo[b,f][1,4]thiazepin-11(10H)-one 
• 1192928-15-6 N-(4-chloro-3-(4-chlorophenylcarbamoyl)phenylcarbamothioyl)-3,4,5-trimethoxybenzamide 
• 22361-84-8 2-(2-Methoxy-phenylamino)-5-nitro-benzoic acid methyl ester 
• 54550-67-3 C₂₂H₁₇N₃O₉ 
• 5291-56-5 2-(2-methoxyphenylamino)-5-nitrobenzoic acid 
• 6307-82-0 2-chloro-5-nitro-benzoic acid methyl ester 
• 90234-03-0 C₁₅H₁₅Cl₂N₃O₃S 
• 111362-52-8 5-amino-2-chloro-N-(4-chlorophenyl)benzamide 
• 2516-96-3 2-chloro-5-nitrobenzoic acid 

Relevant articles and documents

Optimization of chloronitrobenzamides (CNBs) as therapeutic leads for human African trypanosomiasis (HAT)

We previously reported the discovery of the activity of chloronitrobenzamides (CNBs) against bloodstream forms of Trypanosoma brucei. Herein we disclose extensive structure-activity relationship and structure-property relationship studies aimed at identification of tractable early leads for clinical development. These studies revealed a promising lead compound, 17b, that exhibited nanomolar potency against T. brucei (EC 50 = 27 nM for T. b. brucei, 7 nM for T. b. rhodesiense, and 2 nM for T. b. gambiense) with excellent selectivity for parasite cells relative to mammalian cell lines (EC50 > 25 μM). In addition compound 17b displayed suitable physiochemical characteristics and microsomal stability (t1/2 > 4 h for human and mouse) to justify pursuing in vivo studies.

Synthesis and antitumor activity of novel benzophenone derivatives

Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.