5291-56-5Relevant academic research and scientific papers
Novel P2Y12 receptor antagonists
-
Page/Page column 37; 53-54, (2008/12/08)
The present invention relates to compounds of Formula I, in which A and B are independently CH2, O, S, NH, C=O, C=NH, C=S or C=N-OH; X is NH, O, S, C=O or CH2 and R1-R5 are as defined in claim 1, which are P2Y12 receptor antagonists and useful for treating, alleviating and/or preventing diseases and disorders related to P2Y12 receptor function as well as pharmaceutical compositions comprising such compounds and methods for preparing such compounds. The present invention is further directed to the use of these compounds, alone or in combination with other therapeutic agents, for the alleviation, prevention and/or treatment of diseases and disorders, especially the use as antithrombotic agents for inhibiting platelet aggregation.
Catalyst-free microwave-assisted amination of 2-chloro-5-nitrobenzoic acid
Baqi, Younis,Mueller, Christa E.
, p. 5908 - 5911 (2008/02/10)
(Chemical Equation Presented) The synthesis of N-substituted 5-nitroanthranilic acid derivatives 3a-w was achieved by a new, mild, microwave-assisted, regioselective amination reaction of 5-nitro-2-chlorobenzoic acid (1a) with a diverse range of aliphatic
Convenient access to substituted acridines by a Buchwald-Hartwig amination
Csuk, René,Barthel, Alexander,Raschke, Christian
, p. 5737 - 5750 (2007/10/03)
A convenient, high yield procedure for the synthesis of anthranilic acids carrying a variety of different substituents as well as their straightforward transformation into the corresponding 9-chloroacridines could be established by using modified Buchwald-Hartwig amination conditions.
