54266-41-0

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• 5398-63-0 2,5-diphenylpyrazine 
• 81225-13-0 3,6-diphenyl-pyrazine-2-carbonitrile 
• 859063-98-2 3,6-diphenyl-pyrazine-2,5-dicarbonitrile 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 136611-99-9 C₁₇H₁₄ClN₃O₃S 
• 1189-71-5 isocyanate de chlorosulfonyle 
• 7654-06-0 3-phenyl-2H-azirine 
• 10034-85-2 hydrogen iodide 
• 1088-34-2 3,6-diphenylpyrazin-2(1H)-one 
• 7664-41-7 ammonia 
• 613-89-8 2-Aminoacetophenone 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 613-89-8 2-Aminoacetophenone 
• 1259685-27-2 trans-2,5-Diphenyl-piperazin 
• 5398-63-0 2,5-diphenylpyrazine 

Relevant academic research and scientific papers

A facile synthesis of triazocinones and oxadiazocinones

A facile synthesis of 4,7-diaryl-1,3,6-trihydro-1,3,6-triazocin-2-ones and 5,8-diaryl-3,6-dihydro-1,3,6-oxidiazocin-2-ones is reported by the interaction of chlorosulfonyl isocyanate and 2H-azirines.

Open-chain nitrogen compounds. Part VIII. 1-(2'-Acetylphenyl)-3-alkyltriazenes with reactive substituents in the alkyl group: synthons for five- and six-membered nitrogen heterocycles

The synthesis of a series of 1-(2'-acetylphenyl)-3-alkyltriazenes, with electron-withdrawing α-substituents in the alkyl moiety, is described.The structure of the products from the reaction of 2-acetylbenzenediazonium ion (1) with methylamine has been reinvestigated using high field (360 MHz) nmr spectroscopy.The 2-acetylphenyltriazenes undergo cyclization to five- or six-membered heterocycles, depending on the substituent present in the alkyl group.Attack by N-3 of the triazene on the ortho-acetyl group leads to a 4-methylenetriazine, which can undergo oxidation to a benzotriazinone or acid-catalysed rearrangement to a 4-alkylaminocinnoline.The reaction of 1 with alkylamines also affords red products, which have been identified as 4-arylazomethylenetriazines and fully characterized by 1H and 13C nmr spectroscopy.The formation of these azo compounds is consistent with the enamine character of the 4-methylenetriazines.The introduction of a CO2Et group at the α-position of the alkyl moiety provides a competing cyclization pathway to give a five-membered heterocycle, a 5-hydroxytriazole.In this case the cyclization pathway to the six-membered heterocycle is favoured, whereas the introduction of a CN group can lead to exclusive triazole formation.The reaction of the nitrile (2c) with alumina in chloroform leads to a new heterocycle, a quinazolinotriazole; in DMSO solution, 2c prefers the alternative pathway and gives only the 3-cyanomethyl-4-methylenetriazine.Introduction of a benzoyl group in the alkyl moiety gives an unstable triazene; it reacts with alumina in chloroform to give a triazole, which in turn rearranges to a novel diazoalkane.