5427-93-0

Usage

Uses

Used in Pharmaceutical Research:
4-Bromo-2-phenylquinoline is used as a research compound for its potential pharmacological properties, including antimicrobial, anti-inflammatory, and anti-cancer activities. Its unique structure allows for the development of new drugs targeting various diseases and conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 4-Bromo-2-phenylquinoline is used as a building block or intermediate for the synthesis of more complex organic molecules. Its reactivity and structural features make it a useful component in the creation of novel compounds with specific properties.
Used in Antimicrobial Applications:
4-Bromo-2-phenylquinoline is used as an antimicrobial agent, exhibiting activity against various types of bacteria and other microorganisms. Its ability to disrupt microbial processes makes it a promising candidate for the development of new antibiotics and antifungal agents.
Used in Anti-inflammatory Applications:
As an anti-inflammatory agent, 4-Bromo-2-phenylquinoline is used to reduce inflammation and alleviate symptoms associated with inflammatory conditions. Its potential to modulate inflammatory pathways makes it a valuable tool in the treatment of various diseases characterized by chronic inflammation.
Used in Anti-cancer Applications:
4-Bromo-2-phenylquinoline is used as an anti-cancer agent, showing potential in inhibiting the growth and proliferation of cancer cells. Its ability to target specific cellular processes involved in cancer development and progression makes it a promising candidate for the development of new cancer therapies.
Used in Fluorescent Probes for Biological Imaging and Sensing Applications:
4-Bromo-2-phenylquinoline has demonstrated potential as a fluorescent probe, making it useful in biological imaging and sensing applications. Its fluorescent properties allow for the visualization of cellular structures and processes, as well as the detection of specific biomolecules, providing valuable insights into biological systems and disease mechanisms.

InChI:InChI=1/C15H10BrN/c16-13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H

Upstream product

• 5855-52-7 2-phenylquinolin-4-amine 
• 1144-20-3 2-phenyl-4-quinolinol 
• 7789-69-7 phosphorus pentabromide 
• 180689-33-2 3-(2-aminophenyl)-1-phenyl-2-propyn-1-one 
• 3964-04-3 4-bromoquinoline 
• 98-80-6 phenylboronic acid 
• 1449379-67-2 C₁₅H₁₁N₃O 

Relevant academic research and scientific papers

TMSBr-promoted cascade cyclization of ortho-propynol phenyl azides for the synthesis of 4-bromo quinolines and its applications

Difficult-to-access 4-bromo quinolines are constructed directly from easily prepared ortho-propynol phenyl azides using TMSBr as acid-promoter. The cascade transformation performs smoothly to generate desired products in moderate to excellent yields with good functional groups compatibility. Notably, TMSBr not only acted as an acid-promoter to initiate the reaction, and also as a nucleophile. In addition, 4-bromo quinolines as key intermediates could further undergo the coupling reactions or nucleophilic reactions to provide a variety of functionalized compounds with molecular diversity at C4 position of quinolines.

Silver-Catalyzed Minisci Reactions Using Selectfluor as a Mild Oxidant

A new method for silver-catalyzed Minisci reactions using Selectfluor as a mild oxidant is reported. Heteroarenes and quinones both participate in radical C-H alkylation and arylation from a variety of carboxylic and boronic acid radical precursors. Several oxidatively sensitive and highly reactive radical species are successful, providing structures that are challenging to access by other means.

Synthesis of 4-haloquinolines and their fused polycyclic derivatives

A general method for the synthesis of 4-chloro- or 4-bromo-substituted quinolines and quinoline moieties of polycyclic compounds includes the addition of hydrogen halides to vic-amino(3-oxoalk-1-ynyl)arenes under mild conditions followed by the intramolecular cyclization of the adducts.