180689-33-2

Upstream product

• 52670-38-9 2-ethynylaniline 
• 98-88-4 benzoyl chloride 
• 615-43-0 2-iodophenylamine 
• 197729-98-9 α-[2-(2-aminophenyl)ethynyl]benzenemethanol 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 199454-06-3 (2-ethynylphenyl)carbamic acid 1,1-dimethylethyl ester 

Downstream Products

• 5427-93-0 4-bromo-2-phenylquinoline 
• 155057-20-8 4-nitro-2-phenylquinoline 
• 5855-52-7 2-phenylquinolin-4-amine 
• 14802-18-7 2-phenyl-1H-quinolin-4-one 
• 109809-45-2 N,N-dimethyl-2-phenylquinolin-4-amine 
• 1022-86-2 2-benzoylindole 

Relevant academic research and scientific papers

TBAF-Catalyzed Tandem Synthesis of Triazolo[4,5-c]quinolines at Ambient Temperature

A mild, efficient and metal-free synthetic method for 1H-[1,2,3]triazolo[4,5-c]quinolines has been developed via intermolecular [3+2] cycloaddition of β-(2-aminoaryl)-α,β-ynones and TMS-N3, followed by intramolecular dehydration annulation sequential reactions. With 5 mmol-% of TBAF as catalyst, the reaction can smoothly proceed in DMF at ambient temperature to afford a wide range of functionalized 1H-[1,2,3]triazolo[4,5-c]quinolines in good to excellent yields.

An Improved Environmentally Friendly Approach to 4-Nitro-, 4-Sulfonyl-, and 4-Aminoquinolines and 4-Quinolones through Conjugate Addition of Nucleophiles to β-(2-Aminophenyl)-α,β-ynones

Sequential addition/annulation reactions of sulfinate and nitrite anions to β-(2-aminophenyl)-α,β-ynones led to valuable 4-sulfonylquinolines and 4-nitroquinolines. The latter proved to be versatile precursors of N-unsubstituted 4-aminoquinolines and 4-quinolones. Reaction of β-(2-aminophenyl)-α,β-ynones with DMF/NaOH resulted in the formation of 4-(dimethylamino)quinolines. The use of an alternative CO-free procedure for the preparation of substrates β-(2-aminophenyl)-α,β-ynones allowed extension of the methodology to the synthesis of 4-substituted 2-alkylquinolines.

A facile and rapid route for the synthesis of Cu/Cu2O nanoparticles and their application in the Sonogashira coupling reaction of acyl chlorides with terminal alkynes

We have demonstrated a facile one-step synthetic strategy for the preparation of Cu/Cu2O nanoparticles (NPs) via a microwave method. The microwave energy acts as a driving force for the synthesis of Cu/Cu2O NPs, which makes the proce

Efficient preparation of 4-hydroxyquinolin-2(1 H)-one derivatives with silver-catalyzed carbon dioxide incorporation and intramolecular rearrangement

Although 4-hydroxyquinolin-2(1H)-one derivatives have attracted much attention due to their biological benefits, conventional reactions under harsh heat conditions must be employed to provide these key compounds. In the presence of a catalytic amount of s

The cyclization of vicinal 1-amino-2-acylvinylated derivatives of aromatic amines

A general method for the synthesis of substituted fused polycyclic compounds containing a 4-slkylsmino- or 4-dialkylaminopyridine cycle has been proposed.The method includes the addition of primary or secondary amines to vicinal (acylethynyl)arylamines fo