1144-20-3Relevant articles and documents
An efficient oxidation of 2-aryl-1,2,3,4-tetrahydro-4-quinolones employing ferric chloride hexahydrate-methanol: Synthesis of naturally occurring 4-alkoxy-2-arylquinolines
Kumar, K. Hemanth,Muralidharan,Perumal
, p. 7903 - 7906 (2004)
A simple, inexpensive and efficient oxidation of 2-aryl-1,2,3,4-tetrahydro- 4-quinolones has been carried out by employing FeCl3·6H 2O-methanol under mild conditions. This method has been investigated for the synthesis of an endothel
Palladium catalyzed hydrodefluorination of fluoro-(hetero)arenes
Gair, Joseph J.,Grey, Ronald L.,Giroux, Simon,Brodney, Michael A.
supporting information, p. 2482 - 2487 (2019/04/10)
Palladium catalyzed hydrodefluorination was developed for fine-tuning the properties of fluoro-(hetero)aromatic compounds. The robust reaction can be set up in air, requires only commercially available components, and tolerates a variety of heterocycles and functionalities relevant to drug discovery. Given the prevalence of fluorine incorporation around metabolic hotspots, the corresponding deuterodefluorination reaction may prove useful for converting fluorinated libraries to deuterated analogues to suppress the oxidative metabolism by kinetic isotope effects.
Enzymatic resolution of 1-amino-2-vinylcyclopropyl caboxylic acid methyl ester
-
, (2008/06/13)
An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase?, is disclosed.