1144-20-3

Usage

Uses

4-Hydroxy-2-phenylquinoline (cas# 1144-20-3) is a useful bacterial efflux pump inhibitor.

Synthesis Reference(s)

Journal of the American Chemical Society, 68, p. 1270, 1946 DOI: 10.1021/ja01211a041

InChI:InChI=1/C15H11NO/c17-15-10-14(11-6-2-1-3-7-11)16-13-9-5-4-8-12(13)15/h1-10H,(H,16,17)

Upstream product

• 6011-26-3 2'-acetylbenzanilide 
• 22680-63-3 4-ethoxy-2-phenylquinoline 
• 742-29-0 N-(2-phenyl-4-quinolyl)aniline 
• 53256-22-7 ethyl β-anilinocinnamate 
• 35401-49-1 β-anilino-cinnamic acid methyl ester 
• 47057-64-7 1-(2-nitro-phenyl)-3-phenyl-propane-1,3-dione 
• 132962-66-4 3-amino-2-(α-phenylimino-benzyl)-crotonic acid methyl ester 
• 110422-10-1 3-amino-2-(α-phenylimino-benzyl)-crotonic acid ethyl ester 
• 109932-66-3 β-diethylamino-2-nitro-chalcone 
• 113751-88-5 β-(cyclohexyl-methyl-amino)-2-nitro-chalcone 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 118-92-3 anthranilic acid 
• 98-86-2 acetophenone 
• 101-84-8 diphenylether 

Downstream Products

• 612-96-4 2-Phenylquinoline 
• 5855-52-7 2-phenylquinolin-4-amine 
• 4979-79-7 4-chloro-2-phenylquinoline 
• 5427-93-0 4-bromo-2-phenylquinoline 
• 6639-96-9 3-bromo-2-phenyl-quinolin-4-ol 
• 22680-62-2 4-methoxy-2-phenyl-quinoline 
• 17182-60-4 N-methyl-2-phenylquinolin-4(1H)-one 
• 5428-22-8 3,4-Dibrom-2-phenyl-chinolin 
• 923590-76-5 C₂₆H₂₈N₂O₅ 
• 1313356-82-9 2-phenylquinolin-4-yl 4-nitrobenzenesulfonate 

Relevant academic research and scientific papers

An efficient oxidation of 2-aryl-1,2,3,4-tetrahydro-4-quinolones employing ferric chloride hexahydrate-methanol: Synthesis of naturally occurring 4-alkoxy-2-arylquinolines

A simple, inexpensive and efficient oxidation of 2-aryl-1,2,3,4-tetrahydro- 4-quinolones has been carried out by employing FeCl3·6H 2O-methanol under mild conditions. This method has been investigated for the synthesis of an endothel

Palladium catalyzed hydrodefluorination of fluoro-(hetero)arenes

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Lewis Acid Promoted Oxonium Ion Driven Carboamination of Alkynes for the Synthesis of 4-Alkoxy Quinolines

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The iminoketene generated from anthranilic acid and thionyl chloride reacted with ketones to afford 4-hydroxyquinoline derivatives in good yields.

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An enantiomeric-resolving process for obtaining (1R,2S)-1-amino-2-vinylcyclopropyl carboxylic acid methyl ester by use of an esterase, and especially Alcalase?, is disclosed.

An Unusual Base-Mediated Cyclization of Ketimines Derived from 2-(Trifluoromethyl)aniline That Involves the Trifluoromethyl Group: An Expedient Route to 2-Arylquinolines

6-(Substituted methylene)-N-(arylalkylidene)-2,4-cyclohexadien-1-imines, such as 13, 17, and 21 (Scheme II) are suggested intermediates in a novel synthetic route to 2-arylquinolines based on the reaction of trifluoromethyl-substituted ketimines, such as

Synthesis of Simple Quinoline Alkaloids. A Novel Quinazoline Synthesis

2-Alkyl (aryl), 4-amino-substituted quinolines are prepared in two steps by cycloaddition of 2-nitrobenzaldoximes with acetylenes and subsequent reductive cleavage of the intermediate isoxazole in acetic acid.Diazotization of the 4-aminoquinolines gives t