54316-51-7Relevant academic research and scientific papers
Electrochemical oxidative cyclization of: N -allylcarboxamides: Efficient synthesis of halogenated oxazolines
He, Yanyang,Liu, Chenwei,Wu, Xiao-Feng,Yin, Yanzhao,Yin, Zhiping
supporting information, p. 663 - 667 (2022/01/22)
Herein, we reported an efficient and sustainable intramolecular electrochemical cyclization of N-allylcarboxamides for the synthesis of various halogenated oxazolines. This method was conducted in a simple undivided cell by employing lithium halogen salts
A Photosensitizer-Free Radical Cascade for Synthesizing CF3-Containing Polycyclic Quinazolinones with Visible Light
Hu, Qiang,Yu, Wan-Lei,Luo, Yong-Chun,Hu, Xiu-Qin,Xu, Peng-Fei
supporting information, p. 1493 - 1501 (2022/02/07)
Herein, we report an efficient photoinduced radical tandem trifluoromethylation/cyclization reaction of N-cyanamide alkenes for the synthesis of functionalized quinazolinones. Importantly, the reaction is carried out under mild conditions without any addi
Efficient synthesis of SCF3-substituted tryptanthrins by a radical tandem cyclization
Guo, Jincheng,Hao, Yanan,Li, Gang,Li, Yongqiang,Liu, Yuxiu,Wang, Qingmin,Wang, Ziwen
supporting information, p. 1994 - 2001 (2020/03/23)
Herein, we report a new, efficient and atom-economical strategy for the synthesis of SCF3-substituted tryptanthrin derivatives. These previously unreported derivatives were obtained by means of a radical tandem cyclization. The reaction was triggered by addition of a SCF3 radical to a carbon-carbon double bond and involved the formation of a C(sp3)-SCF3 bond, a C(sp2)-C bond, and a C(sp2)-N bond. This method has mild conditions and a wide range of substrates which is particularly useful for the preparation of substituted indolquinazoline derivatives that widely exist in many natural products, but are not easy to obtain by conventional approaches.
Tri-fluoro methyl quinazolinone derivative and its preparation method and application (by machine translation)
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Paragraph 0046, (2017/08/26)
The invention discloses a containing three fluoro methyl quinazoline ketone compound and its preparation method and application, the preparation method comprises the following steps: copper and in the presence of a ligand, N - cyano substituted compound i
Copper-Catalyzed Divergent Trifluoromethylation/Cyclization of Unactivated Alkenes
Zheng, Jing,Deng, Ziyang,Zhang, Yan,Cui, Sunliang
supporting information, p. 746 - 751 (2016/03/09)
Most of the precedent copper-catalyzed trifluoromethylation reactions of unactivated alkenes concern terminal alkenes, and these processes are terminated in elimination, or nucleophilic addition, or semipinacol rearrangement, or C-H bond functionalization steps. In this study, we develop a trifluoromethylation method for both unactivated terminal and internal alkenes to enable divergent late-stage radical cyclization and achieve high molecular complexity. These cyclizations are well consistent with Baldwin's rule. Furthermore, a kinetic isotope effect (KIE) study and control reactions were conducted, and a plausible mechanism is proposed.
Tetrahydro-1,5-benzoxazepines and tetrahydro-1H-1,5-benzodiazepines by a tandem reduction-reductive amination reaction
Bunce, Richard A.,Smith, Christopher L.,Lewis, Jason R.
, p. 963 - 970 (2007/10/03)
A tandem reduction-reductive amination reaction has been applied to the synthesis of (±)-4-alkyl-2,3,4,5-tetrahydro-1,5-benzoxazepines and (±)-4-alkyl-1-benzoyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepines. The nitro aldehydes and ketones required for 1,5-be
