5432-74-6

Basic information

• Product Name: 2,3-dimethylquinoxaline 1,4-dioxide
• Synonyms: 2,3-dimethylquinoxaline 1,4-dioxide
• CAS NO: 5432-74-6
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.22
• Mol File: 5432-74-6.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 325.7°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.2167 (rough estimate)
• Refractive Index: 1.6300 (estimate)
• CAS DataBase Reference: 2,3-dimethylquinoxaline 1,4-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dimethylquinoxaline 1,4-dioxide(5432-74-6)
• EPA Substance Registry System: 2,3-dimethylquinoxaline 1,4-dioxide(5432-74-6)

Safety Data

• Hazardous Substances Data: 5432-74-6(Hazardous Substances Data)

Usage

General Description

2,3-dimethylquinoxaline 1,4-dioxide is a chemical compound containing a quinoxaline ring with two methyl groups and two oxygen atoms at the 1 and 4 positions. It is a heterocyclic aromatic compound with potential applications in organic synthesis and pharmaceutical research. 2,3-dimethylquinoxaline 1,4-dioxide has been studied for its potential as an anti-cancer agent and for its antibacterial properties. It is also used in the production of various pharmaceuticals and agrochemicals. 2,3-dimethylquinoxaline 1,4-dioxide is a versatile compound with promising biological and industrial applications.

InChI:InChI=1/C10H10N2O2/c1-7-8(2)12(14)10-6-4-3-5-9(10)11(7)13/h3-6H,1-2H3

Upstream product

• 2379-55-7 2,3-dimethylquinoxaline 
• 480-96-6 benzofurazan oxide 
• 78-93-3 butanone 
• 95-54-5 1,2-diamino-benzene 
• 236092-93-6 benzofuroxane N-oxide 
• 88-74-4 2-nitro-aniline 

Downstream Products

• 2379-55-7 2,3-dimethylquinoxaline 
• 6940-11-0 2,3-dimethylquinoxaline monoxide 
• 111557-78-9 2,11-Diphenyl-dipyrrolo[1,2-a;2',1'-c]quinoxaline-3,10-dicarboxylic acid dimethyl ester 
• 17357-92-5 3-methylquinoxaline-2-carboxamide 
• 113729-35-4 2,3-dimethylquinoxaline-5-carboxamide 
• 32387-87-4 2,3-dimethylquinoxaline-6-carboxamide 
• 17357-88-9 3-methyl-2-quinoxalinecarbonitrile 
• 18080-67-6 2,3-bis(bromomethyl)quinoxaline 1,4-di-N-oxide 
• 71569-65-8 3-methyl-1,4-dioxy-quinoxaline-2-carbaldehyde phenylhydrazone 
• 7065-97-6 2,3-bis(hydroxymethyl)quinoxaline 
• 10103-89-6 2,3-bis(acetoxymethyl)-quinoxaline-1,4-di-N-oxide 

Relevant articles and documents

New 1,4-di-N-oxide-quinoxaline-2-ylmethylene isonicotinic acid hydrazide derivatives as anti-Mycobacterium tuberculosis agents

The increase in the prevalence of drug-resistant tuberculosis cases demonstrates the need of discovering new and promising compounds with antimycobacterial activity. As a continuation of our research and with the aim of identifying new antitubercular drugs candidates, a new series of quinoxaline 1,4-di-N-oxide derivatives containing isoniazid was synthesized and evaluated for in vitro anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv strain. Moreover, various drug-like properties of new compounds were predicted. Taking into account the biological results and the promising drug-likeness profile of these compounds, make them valid leads for further experimental research.

Preparation method of 2, 3-quinoxaline-1, 4-dioxide

The invention discloses a preparation method of 2, 3-quinoxaline-1, 4-dioxide, and belongs to the field of synthesis of medical intermediates. The method comprises the following steps: performing condensation cyclization on 1, 2-phenylenediamine serving as a raw material and 2, 3-butanedione to obtain 2, 3-dimethyl quinoxaline, and oxidizing the 2, 3-dimethyl quinoxaline with hydrogen peroxide under the action of a catalyst to obtain 2, 3-dimethyl quinoxaline-1, 4-dioxide; carrying out rearrangement and hydrolysis on the 2, 3-dimethyl quinoxaline-1, 4-dioxide and acid anhydride to obtain 2, 3-quinoxaline dimethanol; and finally, oxidizing the 2, 3-quinoxaline-1, 4-dioxide with hydrogen peroxide under the action of a catalyst to obtain the 2, 3-quinoxaline-1, 4-dioxide. By adopting the process route, the initial raw materials are easy to obtain, the cost is low, the total yield is as high as 64%, and industrial operation is facilitated.

Synthesis, biological evaluation and structure-activity relationships of new quinoxaline derivatives as anti-Plasmodium falciparum agents

We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity