5433-10-3

Usage

Uses

Used in Pharmaceutical Industry:
3-[(E)-(4-methoxyphenyl)methylidene]aminopropan-1-ol is used as a pharmaceutical intermediate for the synthesis of various medicinal compounds. Its unique structure allows it to be a key component in the development of new drugs, potentially offering novel therapeutic options for a range of medical conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 3-[(E)-(4-methoxyphenyl)methylidene]aminopropan-1-ol serves as a versatile building block. Its reactivity and functional groups enable it to participate in a variety of chemical reactions, facilitating the creation of complex organic molecules for use in various applications.
Used in Research and Development:
3-[(E)-(4-methoxyphenyl)methylidene]aminopropan-1-ol is utilized as a research compound in academic and industrial laboratories. Its unique properties and potential applications make it an interesting subject for scientific exploration, with the aim of uncovering new uses and understanding its behavior in different chemical environments.

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 156-87-6 propan-1-ol-3-amine 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 91340-37-3 3-{[(4-methoxyphenyl)methyl]amino}propan-1-ol 

Relevant academic research and scientific papers

Olefin Amine (OLA) Reagents for the Synthesis of Bridged Bicyclic and Spirocyclic Saturated N-Heterocycles by Catalytic Hydrogen Atom Transfer (HAT) Reactions

Spiro- and bridged bicyclic structures are in demand for their sp3-rich frameworks that offer unique physiochemical properties and precisely positioned substituent groups. In order to rapidly access such molecules in a cross-coupling fashion we describe olefin amine (OLA) reagents for the transformation of aldehydes and ketones into all three topological types of bicyclic N-heterocycles: bridged, spiro-, and fused rings. The OLA reagents are easily prepared and allow the synthesis of complex molecular frameworks under operationally simple conditions that tolerate a wide array of functional groups. Investigations into the Mn or Fe promoted reaction pathway support a metal hydride hydrogen atom transfer (MH-HAT) to generate a C-centered radical that undergoes addition to an unactivated imine, leading to an N-centered radical. A catalytic cycle featuring regeneration of the metal catalyst by O2 and a second HAT to form the unprotected saturated N-heterocycle appears to be operative.

Synthesis and antimalarial activity of new nanocopolymer β-lactams and molecular docking study of their monomers

This report describes the preparation of some new β-lactam nanocopolymers. These nanoparticles are synthesized in water by emulsion polymerization of an acrylate β-lactam pre-dissolved in a mixture of co-monomers in the presence of sodium dodecyl sulfate as a surfactant and potassium persulfate as a radical initiator. Dynamic light scattering analysis and electron microscopy images of these emulsions show that the nanoparticles are approximately 30-70 nm in diameter. These compounds have been evaluated for their antimalarial activities against chloroquine-resistant Plasmodium faliparum K1 strain demonstrating IC50 varying from 14 to 50 μM. The interactions between these β-lactam nanocopolymers and the P. falciparum single-stranded DNA-binding proteins have been studied by molecular docking calculations.

Nano-tube TiO2 as a new catalyst for eco-friendly synthesis of imines in sunlight

Nanomaterials are considered as suitable heterogeneous catalysts for many organic reactions. Herein nano-tube TiO2 has been reported as a heterogeneous catalyst, for synthesis of imines in sunlight at room temperature under solvent-free conditions. The condensation of less electrophilic carbonyl compounds with poorly nucleophilic amines was afforded imines in excellent yields.

3-[1,4]OXAZEPANE-4-PYRIMIDONE DERIVATIVES

A compound represented by the formula (I) or a pharmaceutically acceptable salt thereof: wherein Z represents nitrogen atom, C-F or the like; R1 represents a C1-C3 alkyl group; Y represents oxygen atom or N-R7; R2, R3, R4, R5, R6 and R7 each independently represents hydrogen atom, a C1-C6 alkyl group, or a group represented by the formula (II): which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase 1 hyperactivity such as a neurodegenerative diseases (e.g. Alzheimer disease).

SIMPLE SYNTHESIS OF 3-(N-ALKYLAMINO)-1-PROPANOLS

Various 3-(N-alkylamino)-1-propanols were obtained by the lithium aluminum hydride reduction of the products of the reaction of 3-amino-1-propanol with carbonyl compounds.This method for the synthesis of aminopropanols is applicable in the case of optimal electrophilicity of the carbonyl component.